Genetic and non-genetic mechanisms of inflammation may promote transformation in leukemia

被引：3
|
作者：
Vyas, Paresh [1 ]
机构：
[1] Univ Oxford, Oxford Biomed Res Ctr Hematol Theme, Oxford Ctr Haematol, Weatherall Inst Mol Med,MRC Mol Haematol Unit, Oxford, England
来源：
CELL STEM CELL | 2022年 / 29卷 / 02期
关键词：
CLONAL HEMATOPOIESIS; RISK;
D O I：
10.1016/j.stem.2022.01.006
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Non-genetic mechanisms of transformation are still relatively understudied and poorly understood. In this issue of Cell Stem Cell, Muto et al. provide preclinical evidence that loss of TRAF6 expression promotes transformation through a MYC-dependent mechanism that may be modulated by environmental inflammatory signals.
引用
收藏
页码：184 / 186
页数：3
相关论文
共 50 条
  • [31] The genetic and non-genetic toxicity of the fungicide Vinclozolin
    Hrelia, P
    Fimognari, C
    Maffei, F
    Vigagni, F
    Mesirca, R
    Pozzetti, L
    Paolini, M
    Forti, GC
    MUTAGENESIS, 1996, 11 (05) : 445 - 453
  • [32] Mechanisms of non-genetic, provoked seizures in the neonatal and infant brain
    Baram, TZ
    Hatalski, CG
    CHILDHOOD EPILEPSIES AND BRAIN DEVELOPMENT, 1999, 14 : 145 - 156
  • [33] Molecular mechanisms of non-genetic aberrant peptide production in cancer
    Wernaart, Demi
    Fumagalli, Amos
    Agami, Reuven
    ONCOGENE, 2024, 43 (27) : 2053 - 2062
  • [34] Non-genetic phenomenons of radiosensitivity
    van Beuningen, D
    RADIATION BIOLOGY AND RADIATION PROTECTION: INDIVIDUAL RADIOSENSITIVITY AND ITS SIGNIFICANCE FOR RADIATION PROTECTION, 2000, : 41 - 48
  • [35] Non-genetic recurring fevers
    Vidal, E.
    REVUE DE MEDECINE INTERNE, 2006, 27 : S261 - S263
  • [36] Chorea: non-genetic causes
    Cardoso, F
    CURRENT OPINION IN NEUROLOGY, 2004, 17 (04) : 433 - 436
  • [37] Genetic Mechanisms of Chronic Myeloid Leukemia Blastic Transformation
    Skorski, Tomasz
    CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 2012, 7 (02) : 87 - 93
  • [38] Genetic Mechanisms of Chronic Myeloid Leukemia Blastic Transformation
    Tomasz Skorski
    Current Hematologic Malignancy Reports, 2012, 7 : 87 - 93
  • [39] A Nexus between Genetic and Non-Genetic Mechanisms Guides KRAS Inhibitor Resistance in Lung Cancer
    Kulkarni, Prakash
    Mohanty, Atish
    Ramisetty, Sravani
    Duvivier, Herbert
    Khan, Ajaz
    Shrestha, Sagun
    Tan, Tingting
    Merla, Amartej
    El-Hajjaoui, Michelle
    Malhotra, Jyoti
    Singhal, Sharad
    Salgia, Ravi
    BIOMOLECULES, 2023, 13 (11)
  • [40] Genetic and non-genetic mechanisms contribute to long term clonal growth dynamics and therapy resistance
    Dick, John E.
    CANCER RESEARCH, 2014, 74 (19)
12345