Risk Factors for Illness Severity Among Pregnant Women With Confirmed Severe Acute Respiratory Syndrome Coronavirus 2 Infection-Surveillance for Emerging Threats to Mothers and Babies Network, 22 State, Local, and Territorial Health Departments, 29 March 2020-5 March 2021

被引：65

作者：

Galang, Romeo R. ^{[1
]}

Newton, Suzanne M. ^{[1
]}

Woodworth, Kate R. ^{[1
]}

Griffin, Isabel ^{[1
]}

Oduyebo, Titilope ^{[1
]}

Sancken, Christina L. ^{[1
]}

Olsen, Emily O'Malley ^{[1
]}

Aveni, Kathryn ^{[2
]}

Wingate, Heather ^{[3
]}

Shephard, Hanna ^{[4
]}

Fussman, Chris ^{[5
]}

Alaali, Zahra S. ^{[6
]}

Silcox, Kristin ^{[7
]}

Siebman, Samantha ^{[8
]}

Halai, Umme-Aiman ^{[9
]}

Lopez, Camille Delgado ^{[10
]}

Lush, Mamie ^{[11
]}

Sokale, Ayomide ^{[12
]}

Barton, Jerusha ^{[13
]}

Chaudhary, Ifrah ^{[14
]}

Patrick, Paul H. ^{[15
]}

Schlosser, Levi ^{[16
]}

Reynolds, Bethany ^{[17
]}

Gaarenstroom, Nicole ^{[18
]}

Chicchelly, Sarah ^{[19
]}

Read, Jennifer S. ^{[20
,21
]}

de Wilde, Leah ^{[22
]}

Mbotha, Deborah ^{[23
]}

Azziz-Baumgartner, Eduardo ^{[1
]}

Hall, Aron J. ^{[1
]}

Tong, Van T. ^{[1
]}

Ellington, Sascha ^{[1
]}

Gilboa, Suzanne M. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, COVID 19 Response, Atlanta, GA 30341 USA

[2] New Jersey Dept Hlth, Div Family Hlth Serv, Trenton, NJ USA

[3] Tennessee Dept Hlth, Communicable & Environm Dis & Emergency Preparedn, Nashville, TN USA

[4] Massachusetts Dept Publ Hlth, Bur Family Hlth & Nutr, Boston, MA USA

[5] Michigan Dept Hlth & Human Serv, Maternal & Child Hlth Epidemiol Sect, Lansing, MI USA

[6] New York State Dept Hlth, Div Epidemiol, Albany, NY 12237 USA

[7] Maryland Dept Hlth, Maternal & Child Hlth Bur, Baltimore, MD USA

[8] Minnesota Dept Hlth, Emerging Infect Program, St Paul, MN USA

[9] Los Angeles Cty Dept Publ Hlth, Acute Communicable Dis Control Program, Los Angeles, CA USA

[10] Puerto Rico Dept Hlth, Div Children Special Med Needs, San Juan, PR USA

[11] Nebraska Dept Hlth & Human Serv, Div Publ Hlth, Lincoln, NE USA

[12] Philadelphia Dept Publ Hlth, Div Maternal Child & Family Hlth, Philadelphia, PA USA

[13] Georgia Dept Publ Hlth, Epidemiol Div, Atlanta, GA USA

[14] Houston Hlth Dept, Div Dis Prevent & Control, Houston, TX USA

[15] Oklahoma Dept Hlth, Perinatal & Reprod Hlth Div, Oklahoma City, OK USA

[16] North Dakota Dept Hlth, Div Dis Control, Bismarck, ND USA

[17] Penn Dept Hlth, Bur Epidemiol, Pittsburgh, PA USA

[18] Nevada High Sierra Area Hlth Educ Ctr, Reno, NV USA

[19] Kansas Dept Hlth & Environm, Infect Dis Epidemiol & Response, Topeka, KS USA

[20] Vermont Dept Hlth, Infect Dis Epidemiol, Burlington, VT 05402 USA

[21] Univ Vermont, Larner Coll Med, Burlington, VT USA

[22] US Virgin Isl Dept Hlth, Epidemiol Div, St Croix, VI USA

[23] Washington State Dept Hlth, Off Communicable Dis Epidemiol, Washington, DC USA

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 73卷

关键词：

SARS-CoV-2; COVID-19; pregnancy; illness severity; risk factors;

D O I：

10.1093/cid/ciab432

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Pregnant women with coronavirus disease 2019 (COVID-19) are at increased risk for severe illness compared with nonpregnant women. Data to assess risk factors for illness severity among pregnant women with COVID-19 are limited. This study aimed to determine risk factors associated with COVID-19 illness severity among pregnant women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods. Pregnant women with SARS-CoV-2 infection confirmed by molecular testing were reported during 29 March 2020-5 March 2021 through the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET). Criteria for illness severity (asymptomatic, mild, moderate-to-severe, or critical) were adapted from National Institutes of Health and World Health Organization criteria. Crude and adjusted risk ratios for moderate-to-severe or critical COVID-19 illness were calculated for selected demographic and clinical characteristics. Results. Among 7950 pregnant women with SARS-CoV-2 infection, moderate-to-severe or critical COVID-19 illness was associated with age 25 years and older, healthcare occupation, prepregnancy obesity, chronic lung disease, chronic hypertension, and pregestational diabetes mellitus. Risk of moderate-to-severe or critical illness increased with the number of underlying medical or pregnancy-related conditions. Conclusions. Older age and having underlying medical conditions were associated with increased risk of moderate-to-severe or critical COVID-19 illness among pregnant women. This information might help pregnant women understand their risk for moderate-to-severe or critical COVID-19 illness and can inform targeted public health messaging.

引用

页码：S17 / S23

页数：7

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