New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: Synthesis, Structure, and Analgesic Activity

被引：0
|
作者：
Krivokolysko, D. S. [1 ]
Dotsenko, V. V. [2 ,3 ]
Bibik, E. Yu [1 ]
Samokish, A. A. [1 ]
Venidiktova, Yu S. [1 ]
Frolov, K. A. [4 ]
Krivokolysko, S. G. [4 ]
Vasilin, V. K. [5 ]
Pankov, A. A. [4 ]
Aksenov, N. A. [3 ]
Aksenova, I., V [3 ]
机构：
[1] St Luke Lugansk State Med Univ, UA-91045 Lugansk, Ukraine
[2] Kuban State Univ, Krasnodar 350040, Russia
[3] North Caucasus Fed Univ, Stavropol 355009, Russia
[4] V Dahl Lugansk State Univ, UA-91034 Lugansk, Ukraine
[5] Kuban State Technol Univ, Krasnodar 350072, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 09期
关键词：
cyanothioacetamide; nicotinonitriles; 1; 4-dihydropyridines; tetrahydropyridines; analgesics; HYBRID MOLECULES; DIHYDROPYRIDINES; PHARMACOLOGY; CHEMISTRY;
D O I：
10.1134/S1070363221090073
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of new hybrid molecules containing 2-furyl and partially saturated pyridine fragments was obtained based on the reaction of cyanothioacetamide with furfural and 1,3-dicarbonyl compounds. The resulting compounds were tested in vivo for analgesic activity (rats) in the orofacial trigeminal pain test. Some the tested compounds showed an antinociceptive effect, superior to that of the reference drug (metamizole sodium).
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收藏
页码：1646 / 1660
页数：15
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