Background Evidence is now evolving of the importance of team management for patients with chronic heart failure. This includes education, patient self-care and physical exercise training. How such programs should be implemented is still under discussion. Aim To assess the efficacy of an in-hospital rehabilitation clinic-based program, we studied its influence on cardiopulmonary parameters and quality of life in an outpatient setting. Methods and results 75 patients (62 male, 13 female, mean age 65 +/- 8 years) underwent an exercise program including education, bicycle ergometer, muscle strength training and the 6-min walk test as a training unit for 4 weeks. Patients were studied at baseline (T1), before discharge (T2) and after a follow-up period of 29.9 +/- 5.5 weeks (T3). Baseline data (T1): left ventricular ejection fraction (LVEF): 33.8 +/- 7.6%, left ventricular end-diastolic volume (LVEDV): 130 +/- 51 ml, peak VO2: 12.3 +/- 4.3 ml/kg, maximum work load (Watt max): 71 +/- 27 W At discharge (T2) and follow-up (T3) LVEF increased to 36.8 +/- 8% and 41.8 +/- 9.2%, LVEDV decreased to 127 +/- 43 ml and 114 +/- 40 ml, peak VO2 increased to 14.1 +/- 5.1 ml/kg and 15.2 +/- 5 ml/kg, and Watt max increased to 84 +/- 28 W and 98 +/- 42 W (all p<0.01). Quality of life improved significantly at discharge and follow-up in nearly all domains and in the summary score for physical health. There were no significant changes for anxiety and depression at T2 and T3. Conclusion A specialized in-hospital rehabilitation program including education, patient self-management and training has a sustained positive effect on cardiopulmonary parameters and physical well-being.