BSA capped Au nanoparticle as an efficient sensitizer for glioblastoma tumor radiation therapy

被引：53

作者：

Chen, Na ^{[1
]}

Yang, Weitao ^{[2
]}

Bao, Yun ^{[1
]}

Xu, Hualin ^{[1
]}

Qin, Songbing ^{[3
]}

Tu, Yu ^{[1
]}

机构：

[1] Soochow Univ, Collaborat Innovat Ctr Radiol Med Jiangsu Higher, Sch Radiat Med & Protect, Coll Med, Suzhou 215123, Peoples R China

[2] Tianjin Univ, Sch Life Sci, Sch Mat Sci & Engn, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China

[3] Soochow Univ, Dept Radiotherapy, Affiliated Hosp 1, Suzhou 200072, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 51期

基金：

中国国家自然科学基金;

关键词：

BOVINE SERUM-ALBUMIN; GOLD NANOPARTICLES; PHOTOTHERMAL THERAPY; CARBON NANOTUBES; ENHANCEMENT; PHOTOSENSITIZER; NANOMATERIALS; EPIDEMIOLOGY; NANOCLUSTERS; TOXICITY;

D O I：

10.1039/c5ra04013b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Radiation therapy has shown encouraging treatment efficacy on many types of tumors. However, the side effects from accumulated high dosage during radiation therapy hindered its wide application in some cases. In this study, BSA capped Au nanoparticles (BSA-AuNPs) are employed as radiation sensitizers, aimed at achieving high efficiency for tumor radiation therapy. Our results showed that BSA-AuNPs with a uniform size of similar to 18 nm can reduce colony formation, and increase the DNA double-strand breaks (DSBs) at 0.5 and 2 h post-irradiation compared with treatment by radiation therapy alone in a U87 glioblastoma cell line. Cell apoptosis at 48 h is enhanced after radiation treatment with BSA-AuNPs as the sensitizers. An enhanced tumor regression is also observed on the group with BSA-AuNPs sensitized radiation therapy. No obvious toxicity is observed for in vitro and in vivo experiments. BSA-AuNPs show potential in tumor therapy as radiosensitizing agents.

引用

页码：40514 / 40520

页数：7

共 43 条

[21] Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors [J].