Advancements in Next-Generation Sequencing

被引:313
作者
Levy, Shawn E. [1 ]
Myers, Richard M. [1 ]
机构
[1] HudsonAlpha Inst Biotechnol, Huntsville, AL 35806 USA
来源
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 17 | 2016年 / 17卷
关键词
sequencing; whole genome; exome; WHOLE-GENOME; SINGLE-MOLECULE; MUTATIONAL PROCESSES; ENZYMATIC AMPLIFICATION; PACIFIC BIOSCIENCES; CANCER GENOME; DATA SETS; DNA; CELL; EXOME;
D O I
10.1146/annurev-genom-083115-022413
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The term next-generation sequencing is almost a decade old, but it remains the colloquial way to describe highly parallel or high-output sequencing methods that produce data at or beyond the genome scale. Since the introduction of these technologies, the number of applications and methods that leverage the power of genome-scale sequencing has increased at an exponential pace. This review highlights recent concepts, technologies, and methods from next-generation sequencing to illustrate the breadth and depth of the applications and research areas that are driving progress in genomics.
引用
收藏
页码:95 / 115
页数:21
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