Characterization of METTL7B to Evaluate TME and Predict Prognosis by Integrative Analysis of Multi-Omics Data in Glioma

被引：11
作者：
Chen, Xiaochuan [1 ]
Li, Chao [2 ]
Li, Ying [1 ]
Wu, Shihong [1 ]
Liu, Wei [1 ]
Lin, Ting [1 ]
Li, Miaomiao [1 ]
Weng, Youliang [1 ]
Lin, Wanzun [3 ]
Qiu, Sufang [1 ,4 ]
机构：
[1] Fujian Med Univ, Fujian Canc Hosp, Canc Hosp, Dept Radiat Oncol, Fuzhou, Peoples R China
[2] Sanming Second Hosp, Dept Oncol, Sanming, Peoples R China
[3] Fudan Univ, Canc Hosp, Shanghai Proton & Heavy Ion Ctr, Dept Radiat Oncol, Shanghai, Peoples R China
[4] Fujian Prov Key Lab Translat Canc Med, Fuzhou, Peoples R China
来源：
FRONTIERS IN MOLECULAR BIOSCIENCES | 2021年 / 8卷
关键词：
glioma; prognosis; immunosuppressive microenvironment; multi-omics; METTL7B; ADJUVANT TEMOZOLOMIDE; GENE-EXPRESSION; GROWTH-FACTOR; GLIOBLASTOMA; RADIOTHERAPY; CONCOMITANT; CANCER; MICE;
D O I：
10.3389/fmolb.2021.727481
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glioma is the most common and aggressive type of primary brain malignant tumor with limited treatment approaches. Methyltransferase-like 7B (METTL7B) is associated with the pathogenesis of several diseases but is rarely studied in glioma. In this study, 1,493 glioma samples (data from our cohort, TCGA, and CGGA) expressing METTL7B were used to explore its prognostic value and mechanism in the immune microenvironment. Results showed that high expression of METTL7B is associated with poor prognosis and abundant immunosuppressive cells. Further, functional enrichment showed that METTL7B is involved in the negative regulation of immunity and carcinogenic signaling pathways. Moreover, a METTL7B-related prognostic signature constructed based on multi-omics showed a good prediction of the overall survival (OS) time of glioma patients. In conclusion, METTL7B is a potential prognostic biomarker. In addition, the prognostic prediction model constructed in this study can be used in clinical setups for the development of novel effective therapeutic strategies for glioma patients and improving overall survival.
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页数：17
相关论文
共 47 条
  • [1] Epigenetic Modification of FOXP3 in Patients With Chronic HIV Infection
    Abdel-Hameed, Enass A.
    Ji, Hong
    Sherman, Kenneth E.
    Shata, Mohamed T. M.
    [J]. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2014, 65 (01) : 19 - 26
  • [2] METTL7B (methyltransferase-like 7B) iden fication as a novel biomarker for lung adenocarcinoma
    Ali, Jawad
    Liu, Wenwen
    Duan, Wenzhe
    Liu, Chang
    Song, Jing
    Ali, Sameen
    Li, Encheng
    Wang, Qi
    [J]. ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8 (18)
  • [3] Treg functional stability and its responsiveness to the microenvironment
    Barbi, Joseph
    Pardoll, Drew
    Pan, Fan
    [J]. IMMUNOLOGICAL REVIEWS, 2014, 259 (01) : 115 - 139
  • [4] Role of differentially expressed genes and long non-coding RNAs in papillary thyroid carcinoma diagnosis, progression, and prognosis
    Cai, Wei-Yang
    Chen, Xiong
    Chen, Li-Ping
    Li, Qian
    Du, Xiao-Jing
    Zhou, Yang-Yang
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, 119 (10) : 8249 - 8259
  • [5] Oncology Meets Immunology: The Cancer-Immunity Cycle
    Chen, Daniel S.
    Mellman, Ira
    [J]. IMMUNITY, 2013, 39 (01) : 1 - 10
  • [6] Identification and Validation of an 11-Ferroptosis Related Gene Signature and Its Correlation With Immune Checkpoint Molecules in Glioma
    Chen, Zhuohui
    Wu, Tong
    Yan, Zhouyi
    Zhang, Mengqi
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [7] Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    Chin, L.
    Meyerson, M.
    Aldape, K.
    Bigner, D.
    Mikkelsen, T.
    VandenBerg, S.
    Kahn, A.
    Penny, R.
    Ferguson, M. L.
    Gerhard, D. S.
    Getz, G.
    Brennan, C.
    Taylor, B. S.
    Winckler, W.
    Park, P.
    Ladanyi, M.
    Hoadley, K. A.
    Verhaak, R. G. W.
    Hayes, D. N.
    Spellman, Paul T.
    Absher, D.
    Weir, B. A.
    Ding, L.
    Wheeler, D.
    Lawrence, M. S.
    Cibulskis, K.
    Mardis, E.
    Zhang, Jinghui
    Wilson, R. K.
    Donehower, L.
    Wheeler, D. A.
    Purdom, E.
    Wallis, J.
    Laird, P. W.
    Herman, J. G.
    Schuebel, K. E.
    Weisenberger, D. J.
    Baylin, S. B.
    Schultz, N.
    Yao, Jun
    Wiedemeyer, R.
    Weinstein, J.
    Sander, C.
    Gibbs, R. A.
    Gray, J.
    Kucherlapati, R.
    Lander, E. S.
    Myers, R. M.
    Perou, C. M.
    McLendon, Roger
    [J]. NATURE, 2008, 455 (7216) : 1061 - 1068
  • [8] de Groot Amber E, 2018, Oncotarget, V9, P20908, DOI 10.18632/oncotarget.24556
  • [9] RNA N6-methyladenosine modification in cancers: current status and perspectives
    Deng, Xiaolan
    Su, Rui
    Weng, Hengyou
    Huang, Huilin
    Li, Zejuan
    Chen, Jianjun
    [J]. CELL RESEARCH, 2018, 28 (05) : 507 - 517
  • [10] The Emerging Roles of RNA Modifications in Glioblastoma
    Dong, Zhen
    Cui, Hongjuan
    [J]. CANCERS, 2020, 12 (03)
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