Regulated Intramembrane Proteolysis: Signaling Pathways and Biological Functions

被引：81

作者：

Lal, Mark ^{[1
]}

Caplan, Michael ^{[2
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, Div Matrix Biol, Stockholm, Sweden

[2] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06510 USA

来源：

PHYSIOLOGY | 2011年 / 26卷 / 01期

关键词：

SECRETASE-MEDIATED CLEAVAGE; P75 NEUROTROPHIN RECEPTOR; POLYCYSTIC KIDNEY-DISEASE; AMYLOID PRECURSOR PROTEIN; CELL-CELL ADHESION; GAMMA-SECRETASE; INTRACELLULAR DOMAIN; PRESENILIN/GAMMA-SECRETASE; BETA-CATENIN; N-CADHERIN;

D O I：

10.1152/physiol.00028.2010

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Intramembrane cleavage of transmembrane proteins is a fundamental cellular process. Several enzymes capable of releasing domains of integral membrane proteins have been described. Transmembrane protein proteolytic cleavage is regulated and involved not only in degrading membrane spanning segments but also in generating messengers that elicit biological responses. This review examines the role of the released functional protein domain in signaling mechanisms regulating an array of cellular and physiological processes.

引用

页码：34 / 44

页数：11

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