Regulated Intramembrane Proteolysis: Signaling Pathways and Biological Functions

被引：81

作者：

Lal, Mark ^{[1
]}

Caplan, Michael ^{[2
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, Div Matrix Biol, Stockholm, Sweden

[2] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06510 USA

来源：

PHYSIOLOGY | 2011年 / 26卷 / 01期

关键词：

SECRETASE-MEDIATED CLEAVAGE; P75 NEUROTROPHIN RECEPTOR; POLYCYSTIC KIDNEY-DISEASE; AMYLOID PRECURSOR PROTEIN; CELL-CELL ADHESION; GAMMA-SECRETASE; INTRACELLULAR DOMAIN; PRESENILIN/GAMMA-SECRETASE; BETA-CATENIN; N-CADHERIN;

D O I：

10.1152/physiol.00028.2010

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Intramembrane cleavage of transmembrane proteins is a fundamental cellular process. Several enzymes capable of releasing domains of integral membrane proteins have been described. Transmembrane protein proteolytic cleavage is regulated and involved not only in degrading membrane spanning segments but also in generating messengers that elicit biological responses. This review examines the role of the released functional protein domain in signaling mechanisms regulating an array of cellular and physiological processes.

引用

页码：34 / 44

页数：11

共 73 条

[1] Furin-, ADAM 10-, and γ-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of β-catenin's transcriptional activity [J].

Anders, Lars ;

Mertins, Philipp ;

Lammich, Sven ;

Murgia, Marta ;

Hartmann, Dieter ;

Saftig, Paul ;

Haass, Christian ;

Ullrich, Axel .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (10) :3917-3934

[2] Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate [J].

Baker, Rosanna P. ;

Young, Keith ;

Feng, Liang ;

Shi, Yigong ;

Urban, Sinisa .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (20) :8257-8262

[3] CD74 is a member of the regulated intramembrane proteolysis-processed protein family [J].

Becker-Herman, S ;

Arie, G ;

Medvedovsky, H ;

Kerem, A ;

Shachar, I .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (11) :5061-5069

[4] Structural basis for intramembrane proteolysis by rhomboid serine proteases [J].

Ben-Shem, Adam ;

Fass, Deborah ;

Bibi, Eitan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (02) :462-466

[5] SorLA signaling by regulated intramembrane proteolysis [J].

Boehm, Christopher ;

Seibel, Nicole M. ;

Henkel, Birgit ;

Steiner, Harald ;

Haass, Christian ;

Hampe, Wolfgang .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (21) :14547-14553

[6] The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor [J].

Brown, MS ;

Goldstein, JL .

CELL, 1997, 89 (03) :331-340

[7] Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans [J].

Brown, MS ;

Ye, J ;

Rawson, RB ;

Goldstein, JL .

CELL, 2000, 100 (04) :391-398

[8] A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60 [J].

Cao, XW ;

Südhof, TC .

SCIENCE, 2001, 293 (5527) :115-120

[9] Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus [J].

Chauvet, V ;

Tian, X ;

Husson, H ;

Grimm, DH ;

Wang, T ;

Hieseberger, T ;

Igarashi, P ;

Bennett, AM ;

Ibraghimov-Beskrovnaya, O ;

Somlo, S ;

Caplan, MJ .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (10) :1433-1443

[10] Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling [J].

Cipolat, Sara ;

Rudka, Tomasz ;

Hartmann, Dieter ;

Costa, Veronica ;

Serneels, Lutgarde ;

Craessaerts, Katleen ;

Metzger, Kristine ;

Frezza, Christian ;

Annaert, Wim ;

D'Adamio, Luciano ;

Derks, Carmen ;

Dejaegere, Tim ;

Pellegrini, Luca ;

D'Hooge, Rudi ;

Scorrano, Luca ;

De Strooper, Bart .

CELL, 2006, 126 (01) :163-175

← 1 2 3 4 5 6 7 8 →