Is the Course of COVID-19 Different during Pregnancy? A Retrospective Comparative Study

被引:9
作者
Januszewski, Marcin [1 ]
Ziuzia-Januszewska, Laura [2 ]
Jakimiuk, Alicja A. [3 ]
Wierzba, Waldemar [1 ,4 ]
Gluszko, Anna [5 ]
Zytynska-Daniluk, Joanna [5 ]
Jakimiuk, Artur J. [1 ,6 ]
机构
[1] Cent Clin Hosp, Minist Interior & Adm, Dept Obstet & Gynecol, PL-02507 Warsaw, Poland
[2] Cent Clin Hosp, Minist Interior & Adm, Dept Otolaryngol, PL-02507 Warsaw, Poland
[3] Cent Clin Hosp, Minist Interior & Adm, Dept Plast Surg, PL-02507 Warsaw, Poland
[4] Univ Humanities & Econ, Satellite Campus Warsaw, PL-01513 Warsaw, Poland
[5] Cent Clin Hosp, Minist Interior & Adm, Dept Neonatol, PL-02507 Warsaw, Poland
[6] Inst Mother & Child Hlth, Ctr Reprod Hlth, PL-01211 Warsaw, Poland
关键词
SARS-CoV-2; COVID-19; clinical course; pregnancy; oxygen flow; inflammatory markers; ferritin; laboratory indicators; SARS-COV-2; INFECTION; WOMEN; OUTCOMES; PNEUMONIA; METAANALYSIS; MANAGEMENT; INFLUENZA; SARS;
D O I
10.3390/ijerph182212011
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The COVID-19 pandemic has challenged health systems around the world. Maternal-foetal medicine, which has been particularly affected, must consider scientific data on the physiological processes occurring in the pregnant woman's body to develop relevant standards of care. Our study retrospectively compared the clinical and laboratory characteristics of 52 COVID-19 pregnant patients with 53 controls. Most of the pregnant patients required medical attention during the third trimester and therefore we propose that vaccination is needed prior to the 30th week of pregnancy. We found no differences between the 2 groups in the course of illness classification system, days of hospital stay, need for oxygen supplementation, need for mechanical ventilation, and ICU admission. Moreover, clinical manifestations and imaging findings were comparable. Pregnant patients needed a greater oxygen flow rate and required high flow oxygen therapy more frequently. Considering pregnancy-related physiological adaptations, we found that COVID-19 infection in pregnant patients is associated with higher levels of inflammatory markers, apart from serum ferritin, than in non-pregnant women, and concluded that biomarkers of cardiac and muscle injury, as well as kidney function, may not be good predictors of COVID-19 clinical course in pregnant patients at the time of admission, but more research needs to be conducted on this topic.
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页数:15
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