Case Report: Multilevel Ossification of the Ligamentum Flavum in a Patient With Spinal Osteoblastoma

被引:1
作者
Montgomery, Canada T. [1 ]
Miranda, Stephen P. [2 ]
Nelson, Ernest [3 ]
Louka, Katie [4 ]
Nasrallah, MacLean [3 ]
Zhang, Paul J. [3 ]
Stein, Joel [5 ]
Petrov, Dmitriy [2 ]
机构
[1] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Hosp Univ Penn, Dept Neurosurg, 3400 Spruce St, Philadelphia, PA 19104 USA
[3] Hosp Univ Penn, Dept Pathol & Lab Med, 3400 Spruce St, Philadelphia, PA 19104 USA
[4] Stony Brook Univ Hosp, Dept Pathol, Stony Brook, NY USA
[5] Hosp Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USA
关键词
spinal osteoblastoma; ossification of the ligamentum flavum; myelopathy; neurosurgery; neurological compromise; INFLAMMATORY CYTOKINES; COMPLICATIONS;
D O I
10.3389/fsurg.2022.890965
中图分类号
R61 [外科手术学];
学科分类号
摘要
Introduction: Spinal osteoblastomas are primary benign bone tumors most commonly presenting as diffuse back pain in young adults. Rarely, spinal osteoblastoma is associated with ossification of the ligamentum flavum (OLF), a form of ectopic bone formation, which can present with myelopathy. This report highlights a unique case of a patient with spinal osteoblastoma, associated OLF, and thoracic myelopathy. Case Description: The patient presented with subtle myelopathy consisting of mid-thoracic back pain, paresthesias, and gait instability. Imaging findings were suggestive of spinal osteoblastoma with multifocal OLF. The patient was consented for thoracic decompression and stabilization at the T6-10 levels. Histopathology confirmed osteoblastoma with associated OLF. At follow up, the patient's neurological symptoms had completely resolved. Conclusion: This case describes management for a rare presentation of osteoblastoma with associated OLF and myelopathy. Surgeons should be wary of disproportionate neurological compromise when spinal osteoblastoma is associated with OLF. Further study is required to elucidate the pathogenesis of this condition.
引用
收藏
页数:6
相关论文
共 15 条
[1]   Osteoid Osteoma and Osteoblastoma [J].
Atesok, Kivanc I. ;
Alman, Benjamin A. ;
Schemitsch, Emil H. ;
Peyser, Amos ;
Mankin, Henry .
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 2011, 19 (11) :678-689
[2]   WIDESPREAD INFLAMMATORY RESPONSE TO OSTEOBLASTOMA - THE FLARE PHENOMENON [J].
CRIM, JR ;
MIRRA, JM ;
ECKARDT, JJ ;
SEEGER, LL .
RADIOLOGY, 1990, 177 (03) :835-836
[3]   Aggravation of Ossified Ligamentum Flavum Lesion Is Associated With the Degree of Obesity [J].
Endo, Tsutomu ;
Koike, Yoshinao ;
Hisada, Yuichiro ;
Fujita, Ryo ;
Suzuki, Ryota ;
Tanaka, Masaru ;
Tsujimoto, Takeru ;
Shimamura, Yukitoshi ;
Hasegawa, Yuichi ;
Kanayama, Masahiro ;
Yamada, Katsuhisa ;
Iwata, Akira ;
Sudo, Hideki ;
Ishii, Misaki ;
Iwasaki, Norimasa ;
Takahata, Masahiko .
GLOBAL SPINE JOURNAL, 2023, 13 (05) :1325-1331
[4]   Osteoblastomas of the spine: a comprehensive review [J].
Galgano, Michael A. ;
Goulart, Carlos R. ;
Iwenofu, Hans ;
Chin, Lawrence S. ;
Lavelle, William ;
Mendel, Ehud .
NEUROSURGICAL FOCUS, 2016, 41 (02)
[5]   Fibroblasts of spinal ligaments pathologically differentiate into chondrocytes induced by recombinant human bone morphogenetic protein-2: Morphological examinations for ossification of spinal ligaments [J].
Hoshi, K ;
Amizuka, N ;
Sakou, T ;
Kurokawa, T ;
Ozawa, H .
BONE, 1997, 21 (02) :155-162
[6]   A systematic review of complications in thoracic spine surgery for ossification of ligamentum flavum [J].
Hou, Xiaofei ;
Chen, Zhongqiang ;
Sun, Chuiguo ;
Zhang, Guangwu ;
Wu, Sijun ;
Liu, Zheng .
SPINAL CORD, 2018, 56 (04) :301-307
[7]   A review of factors predictive of surgical outcome for ossification of the ligamentum flavum of the thoracic spine [J].
Inamasu, Joji ;
Guiot, Bernard H. .
JOURNAL OF NEUROSURGERY-SPINE, 2006, 5 (02) :133-139
[8]   Osteoid osteoma and osteoblastoma of the spine [J].
Kan, Peter ;
Schmidt, Meic H. .
NEUROSURGERY CLINICS OF NORTH AMERICA, 2008, 19 (01) :65-+
[9]  
KOJIMA T, 1992, INT ORTHOP, V16, P75
[10]   Ossification of the ligamentum flavum associated with osteoblastoma: a report of three cases [J].
Okuda, S ;
Myoui, A ;
Nakase, T ;
Wada, E ;
Yonenobu, K ;
Yoshikawa, H .
SKELETAL RADIOLOGY, 2001, 30 (07) :402-406