COMPARISON OF THE PHARMACOKINETIC PROPERTIES OF VANCOMYCIN, LINEZOLID, TIGECYCLIN, AND DAPTOMYCIN

The rapid antibiotic resistance development has created a major demand for new antimicrobial agents that can combat resistant strains such as methicillin resistant S aureus (MRSA) Until a short time ago the glycopeptide vancomycin was the only therapeutic choice in this situation However in recent years some newer agents with different mechanisms of actions have been added to the arsenal and more are on the horizon For a successful therapy it is of vital Importance that these compounds are used judiciously and dosed appropriately The present article reviews the pharmacokinetic properties of vancomycin linezolid tigecycline and daptomycin The first major difference between these compounds is their oral bioavailability Only linezolid can be administered orally whereas vancomycin daptomycin and tigecycline are limited to parenteral use Once in the body they show very different disposition Daptomycin has a very small volume of distribution of 7L indicating very little tissue distribution whereas tigecycline has a very large volume of distribution of 350 500 L Vancomycin and linezolid arc in between with volumes of distribution of approximately 30 and 50 L close to total body water However studies have shown that linezolid shows better tissue penetration than vancomycin Newer studies using microdialysis a new technique that allows direct monitoring of unbound tissue levels support this finding As far as drug elimination daptomycin and vancomycin are mainly eliminated Into the urine and require dosing adjustments in renally impaired patients whereas tigecycline is eliminated into the bile and linezolid is metabolized so that in renal patients no dosing adjustments are needed for these compounds Although the elimination pathways are very different the resulting half lives of linezolid vancomycin and daptomycin are not greatly different and vary from 4 8 h Tigecycline however has much longer half life of up to 1 2 days due to the slow redistribution from tissue binding sites