A new chemoenzymatic Baylis-Hillman approach for the synthesis of enantiomerically enriched umbelactones

被引：25

作者：

Kamal, Ahmed ^{[1
]}

Krishnaji, Tadiparthi ^{[1
]}

Reddy, P. Venkat ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 40期

关键词：

Baylis-hillmati; lipase-resolution; ring-closing metathesis;

D O I：

10.1016/j.tetlet.2007.07.139

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and convenient strategy for the enantioselective synthesis of enantiomerically enriched umbelactones is described utilizing a lipase-mediated resolution protocol, Baylis-Hillman reaction and ring closing metathesis as key steps. The lipase-resolution is carried out using several lipases from various sources in different solvents to afford the required intermediate 8 in good yield and high enantioselectivity. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：7232 / 7235

页数：4

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