A new chemoenzymatic Baylis-Hillman approach for the synthesis of enantiomerically enriched umbelactones

被引：25
作者：
Kamal, Ahmed [1 ]
Krishnaji, Tadiparthi [1 ]
Reddy, P. Venkat [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 40期
关键词：
Baylis-hillmati; lipase-resolution; ring-closing metathesis;
D O I：
10.1016/j.tetlet.2007.07.139
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and convenient strategy for the enantioselective synthesis of enantiomerically enriched umbelactones is described utilizing a lipase-mediated resolution protocol, Baylis-Hillman reaction and ring closing metathesis as key steps. The lipase-resolution is carried out using several lipases from various sources in different solvents to afford the required intermediate 8 in good yield and high enantioselectivity. (C) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：7232 / 7235
页数：4
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