Catechol-O-Methyltransferase Inhibitors Isolated From Thai Propolis

被引：7

作者：

Miyata, Ryo ^{[1
]}

Motoyama, Tomoharu ^{[1
]}

Nakano, Shogo ^{[1
]}

Ito, Sohei ^{[1
]}

Mukaide, Kazuma ^{[1
]}

Vongsak, Boonyadist ^{[2
]}

Kumazawa, Shigenori ^{[1
]}

机构：

[1] Univ Shizuoka, Grad Sch Integrated Pharmaceut & Nutr Sci, Shizuoka, Japan

[2] Burapha Univ, Fac Pharmaceut Sci, Pharmaceut Innovat Nat Prod Unit PhInNat, Chon Buri, Thailand

来源：

NATURAL PRODUCT COMMUNICATIONS | 2021年 / 16卷 / 10期

基金：

日本学术振兴会;

关键词：

propolis; COMT; Parkinson's disease; xanthone; mangostin; prenylflavonoid; mangosteen; Thailand;

D O I：

10.1177/1934578X211050273

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Propolis is an aggregate of functional components found in plant resins and has been reported to exhibit a variety of valuable biological activities. This study investigated the inhibitory properties of propolis from Thailand toward human catechol-O-methyltransferase (COMT), a key neurotransmitter involved in Parkinson's disease and depression. Samples collected from Chanthaburi and Chiang Mai exhibited relatively high inhibitory activity against COMT. gamma-Mangostin (1) and 6-prenyleriodictyol (3) were identified as COMT inhibitors with IC50 values of 62 and 75 mu M, respectively. In an enzyme inhibition assay, 1 exhibited mixed inhibition toward COMT. The results suggest that both 1 and propolis have potential applications in the prevention and treatment of psychological illness.

引用

页数：5

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