Detection of Mycobacterium tuberculosis in urine by Xpert MTB/RIF Ultra: A useful adjunctive diagnostic tool in HIV-associated tuberculosis

被引：28

作者：

Atherton, Rachel R. ^{[1
]}

Cresswell, Fiona V. ^{[1
,2
]}

Ellis, Jayne ^{[1
]}

Skipper, Caleb ^{[1
,4
]}

Tadeo, Kiiza K. ^{[1
]}

Mugumya, Gerald ^{[1
]}

Wadda, Vincent ^{[1
]}

Meya, David B. ^{[1
,3
]}

Boulware, David R. ^{[4
]}

机构：

[1] Infect Dis Inst, Kampala, Uganda

[2] London Sch Hyg & Trop Med, Dept Clin Res, Keppel St, London WC1E 7HT, England

[3] Makerere Univ, Coll Hlth Sci, Upper Mulago Hill Rd, Kampala, Uganda

[4] Univ Minnesota, Minneapolis, MN 55455 USA

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2018年 / 75卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

Mycobacterium tuberculosis; Urine; Xpert MTB/RIF Ultra; Renal tuberculosis; LIPOARABINOMANNAN;

D O I：

10.1016/j.ijid.2018.07.007

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In January 2017, the World Health Organisation recommended the Xpert1 MTB/RIF Ultra assay (Ultra) for tuberculosis (TB) diagnosis. Ultra offers improved analytical sensitivity when compared with the initial Xpert1 MTB/RIF (Xpert) assay for the detection of Mycobacterium tuberculosis. Ultra is therefore likely to be of particular benefit for detecting paucibacillary TB. We present a case from Uganda demonstrating Ultra positivity in urine from an HIV-infected patient presenting with altered mental status and urinary incontinence, and no other signs of active pulmonary or extrapulmonary TB. This represents the first published instance of a diagnosis of extrapulmonary TB made on the basis of a positive urine Ultra assay. The use of Ultra on urine may be a useful addition to the diagnostic armamentarium for disseminated TB in persons with HIV co-infection. The diagnostic accuracy of urine Ultra should be characterised further via prospective studies. (c) 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：92 / 94

页数：3

共 14 条

[1]

[Anonymous], AUT REAL TIM NUCL AC

[2]

[Anonymous], 2014, XPERT MTB RIF IMPL M

[3]

Bahr NC, 2018, LANCET INFECT DIS, V18, P68, DOI [10.1016/s1473-3099(17)30474-7, 10.1016/S1473-3099(17)30474-7]

[4]

Chakravorty S, 2017, MBIO, V8, DOI [10.1128/mbio.00812-17, 10.1128/mBio.00812-17]