Dynamic micro-Hall detection of superparamagnetic beads in a microfluidic channel

被引:13
作者
Aledealat, K. [1 ,2 ]
Mihajlovic, G. [3 ]
Chen, K. [1 ,2 ]
Field, M. [4 ]
Sullivan, G. J.
Xiong, P. [1 ,2 ,5 ]
Chase, P. B. [5 ,6 ]
von Molnar, S. [1 ,2 ,5 ]
机构
[1] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA
[2] Florida State Univ, MARTECH, Tallahassee, FL 32306 USA
[3] San Jose Res Ctr, Hitachi Global Storage Technol, San Jose, CA 95135 USA
[4] Teledyne Sci Company LLC, Thousand Oaks, CA 90360 USA
[5] Florida State Univ, Integrat Nanosci Inst, Tallahassee, FL 32306 USA
[6] Florida State Univ, Dept Biol Sci, Tallahassee, FL 32306 USA
关键词
InAs quantum well; Microfluidics; Superparamagnetic bead; Micro-Hall sensor; SPIN-VALVE SENSORS; MAGNETIC NANOPARTICLES; BIOLOGICAL APPLICATIONS; SYSTEM; BIOSENSORS;
D O I
10.1016/j.jmmm.2010.08.006
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
We report integration of an InAs quantum well micro-Hall magnetic sensor with microfluidics and real-time detection of moving superparamagnetic beads. Beads moving within and around the Hall cross area result in positive and negative Hall voltage signals, respectively. Relative magnitudes and polarities of the signals measured for a random distribution of immobilized beads over the sensor are in good agreement with calculated values and explain consistently the shape of the dynamic signal. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:L69 / L72
页数:4
相关论文
共 24 条
[1]   Detection of a single magnetic microbead using a miniaturized silicon Hall sensor [J].
Besse, PA ;
Boero, G ;
Demierre, M ;
Pott, V ;
Popovic, R .
APPLIED PHYSICS LETTERS, 2002, 80 (22) :4199-4201
[2]   An integrated microfluidic biochemical detection system for protein analysis with magnetic bead-based sampling capabilities [J].
Choi, JW ;
Oh, KW ;
Thomas, JH ;
Heineman, WR ;
Halsall, HB ;
Nevin, JH ;
Helmicki, AJ ;
Henderson, HT ;
Ahn, CH .
LAB ON A CHIP, 2002, 2 (01) :27-30
[3]   Planar Hall effect sensor for magnetic micro- and nanobead detection [J].
Ejsing, L ;
Hansen, MF ;
Menon, AK ;
Ferreira, HA ;
Graham, DL ;
Freitas, PP .
APPLIED PHYSICS LETTERS, 2004, 84 (23) :4729-4731
[4]   Fully integrated detection of single magnetic beads in complementary metal-oxide-semiconductor [J].
Florescu, Octavian ;
Mattmann, Moritz ;
Boser, Bernhard .
JOURNAL OF APPLIED PHYSICS, 2008, 103 (04)
[5]   On-chip manipulation and detection of magnetic particles for functional biosensors [J].
Janssen, X. J. A. ;
van IJzendoorn, L. J. ;
Prins, M. W. J. .
BIOSENSORS & BIOELECTRONICS, 2008, 23 (06) :833-838
[6]   Magnetic biosensors for genetic screening of cystic fibrosis [J].
Lagae, L ;
Wirix-Speetjens, R ;
Liu, CX ;
Laureyn, W ;
Borghs, G ;
Harvey, S ;
Galvin, P ;
Ferreira, HA ;
Graham, DL ;
Freitas, PP ;
Clarke, LA ;
Amaral, MD .
IEE PROCEEDINGS-CIRCUITS DEVICES AND SYSTEMS, 2005, 152 (04) :393-400
[7]   An integrated microfluidic system using magnetic beads for virus detection [J].
Lee, Wan-Chi ;
Lien, Kang-Yi ;
Lee, Gwo-Bin ;
Lei, Huan-Yao .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2008, 60 (01) :51-58
[8]   Spin valve sensors for ultrasensitive detection of superparamagnetic nanoparticles for biological applications [J].
Li, GX ;
Sun, SH ;
Wilson, RJ ;
White, RL ;
Pourmand, N ;
Wang, SX .
SENSORS AND ACTUATORS A-PHYSICAL, 2006, 126 (01) :98-106
[9]   Detection of single micron-sized magnetic bead and magnetic nanoparticles using spin valve sensors for biological applications [J].
Li, GX ;
Joshi, V ;
White, RL ;
Wang, SX ;
Kemp, JT ;
Webb, C ;
Davis, RW ;
Sun, SH .
JOURNAL OF APPLIED PHYSICS, 2003, 93 (10) :7557-7559
[10]   Cell manipulation with magnetic particles toward microfluidic cytometry [J].
Liu, Chengxun ;
Stakenborg, Tim ;
Peeters, Sara ;
Lagae, Liesbet .
JOURNAL OF APPLIED PHYSICS, 2009, 105 (10)