Human regulatory T cells suppress proliferation of B lymphoma cells

被引：15

作者：

Grygorowicz, Monika Anna ^{[1
]}

Biernacka, Marzena ^{[1
]}

Bujko, Mateusz ^{[2
]}

Nowak, Eliza ^{[1
]}

Rymkiewicz, Grzegorz ^{[3
]}

Paszkiewicz-Kozik, Ewa ^{[4
]}

Borycka, Ilona Sara ^{[1
]}

Bystydzienski, Zbigniew ^{[3
]}

Walewski, Jan ^{[4
]}

Markowicz, Sergiusz ^{[1
]}

机构：

[1] Maria Sklodowska Curie Mem Canc Ctr & Inst Oncol, Dept Immunol, 5 WK Roentgen Str, PL-02781 Warsaw, Poland

[2] Maria Sklodowska Curie Mem Canc Ctr & Inst Oncol, Dept Mol & Translat Oncol, Warsaw, Poland

[3] Maria Sklodowska Curie Mem Canc Ctr & Inst Oncol, Dept Pathol & Lab Diagnost, Warsaw, Poland

[4] Maria Sklodowska Curie Mem Canc Ctr & Inst Oncol, Dept Lymphoid Malignancies, Warsaw, Poland

来源：

LEUKEMIA & LYMPHOMA | 2016年 / 57卷 / 08期

关键词：

B-cell lymphoma; dendritic cells; immune regulation; regulatory T cells; tumor immunology; VERSUS-HOST-DISEASE; CHRONIC LYMPHOCYTIC-LEUKEMIA; REED-STERNBERG CELLS; GERMINAL CENTER-LIKE; FOLLICULAR LYMPHOMA; FOXP3; EXPRESSION; CD40; LIGAND; IN-VITRO; EX-VIVO; MEDIATED SUPPRESSION;

D O I：

10.3109/10428194.2015.1121260

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Activated regulatory T cells (Tregs) suppress proliferation and differentiation of normal B cells. In our study, allogeneic polyclonal CD4(+)CD25(+)Tregs and CD4(+)CD25(+)CD127(lo)Tregs expanded in vitro in the presence of rapamycin and low dose IL-2 suppressed proliferation of 11 out of 12 established lymphoma B-cell lines. The effect of expanded CD4(+)CD25(+)Tregs on survival of freshly isolated lymphoma B cells maintained in culture with soluble multimeric CD40L and IL-4 was variable across lymphoma entities. The survival of freshly isolated follicular lymphoma cells usually decreased in cocultures with CD4(+)CD25(+)Tregs. Treg effect on chronic lymphocytic leukemia/small lymphocytic lymphoma cells ranged from suppression to help in individual patients. CD4(+)CD25(+)Tregs or CD4(+)CD25(+)CD127(lo)Tregs expanded ex vivo with rapamycin could be used to suppress regrowth of residual lymphoma after autologous hematopoietic cell transplantation (HCT), and to counteract both graft-versus-host disease and lymphoma re-growth after allogeneic HCT in select patients with lymphoma susceptible to the regulation by Tregs.

引用

页码：1903 / 1920

页数：18

共 99 条

[1] Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells [J].