Abnormal vascular architecture at the placental-maternal interface in placenta increta

被引：74

作者：

Chantraine, Frederic ^{[1
,2
]}

Blacher, Silvia ^{[2
]}

Berndt, Sarah ^{[2
]}

Palacios-Jaraquemada, Jose ^{[3
]}

Sarioglu, Nanette ^{[4
]}

Nisolle, Michelle ^{[1
,2
]}

Braun, Thorsten ^{[5
]}

Munaut, Carine ^{[2
]}

Foidart, Jean-Michel ^{[1
,2
]}

机构：

[1] Univ Liege, Hop Citadelle, Ctr Hosp Univ, Dept Obstet & Gynecol, Liege, Belgium

[2] Univ Liege, Ctr Hosp Univ, GIGA Canc, Lab Tumor & Dev Biol, Liege, Belgium

[3] Univ Buenos Aires, Sch Med, JJ Naon Morphol Inst, Buenos Aires, DF, Argentina

[4] Charite Campus Virchow Klinikum, Dept Pathol, Berlin, Germany

[5] Charite Campus Virchow Klinikum, Dept Obstet, Berlin, Germany

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2012年 / 207卷 / 03期

关键词：

placenta increta; placental bed; vessel architecture; virtual imaging; 3-DIMENSIONAL POWER DOPPLER; ACCRETA; PREVIA; QUANTIFICATION; EXPRESSION; MANAGEMENT; RECEPTORS; DIAGNOSIS; CRETA;

D O I：

10.1016/j.ajog.2012.06.083

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: The objective of the study was to characterize the vascular architecture at the placental-maternal interface in pregnancies complicated by placenta increta and normal pregnancies. STUDY DESIGN: Vessel numbers and cross-section area density and spatial and area distributions in 13 placenta-increta placental beds were compared with 9 normal placental beds using computer-assisted image analysis of whole-slide CD31 immunolabeled sections. RESULTS: The total areas occupied by vessels in normal and placentaincreta placental beds were comparable, but vessels were significantly sparser and larger in the latter. Moreover, placenta-increta-vessel distributions (area and distance from the placental-myometrial junction) were more heterogeneous. CONCLUSION: Size and spatial organization of the placenta-increta vascular architecture at the placental-maternal interface differed from normal and might partially explain the severe hemorrhage observed during placenta-increta deliveries.

引用

页码：188.e1 / 188.e9

页数：9

共 38 条

[1] [Anonymous], AM J OBSTET GYNECOL
[2] Balsat C, 2011, ISRN OBSTET GYNECOL, V2011
[3] Placenta accreta
Belfort, Michael A.
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2010, 203 (05) : 430 - 439
[4] Towards a computer aided diagnosis system dedicated to virtual microscopy based on stereology sampling and diffusion maps
Belhomme, Philippe
Oger, Myriam
Michels, Jean-Jaques
Plancoulaine, Benoit
Herlin, Paulette
[J]. DIAGNOSTIC PATHOLOGY, 2011, 6
[5] Computerized quantification of tissue vascularization using high-resolution slide scanning of whole tumor sections
Chantrain, CF
DeClerck, YA
Groshen, S
McNamara, G
[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2003, 51 (02) : 151 - 158
[6] Three-dimensional color power Doppler imaging in the assessment of uteroplacental neovascularization in placenta previa increta/percreta
Chou, MM
Tseng, JJ
Ho, ESC
Hwang, JI
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2001, 185 (05) : 1257 - 1260
[7] Clark DE, 1996, HUM REPROD, V11, P1090
[8] Long-term maternal morbidity associated with repeat cesarean delivery
Clark, Erin A. S.
Silver, Robert M.
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2011, 205 (06) : S2 - S10
[9] Application of 3-D Angiography in the Management of Placenta Percreta Treated with Repeat Uterine Artery Embolization
El-Messidi, Amira
Morissette, Cathie
Faught, Wylam
Oppenheimer, Lawrence
[J]. JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA, 2010, 32 (08) : 775 - 779
[10] A simple way of quantifying immunostained cell nuclei on the whole histologic section
Elie, N
Plancoulaine, B
Signolle, JP
Herlin, P
[J]. CYTOMETRY PART A, 2003, 56A (01): : 37 - 45

← 1 2 3 4 →