Abnormal vascular architecture at the placental-maternal interface in placenta increta

被引：74

作者：

Chantraine, Frederic ^{[1
,2
]}

Blacher, Silvia ^{[2
]}

Berndt, Sarah ^{[2
]}

Palacios-Jaraquemada, Jose ^{[3
]}

Sarioglu, Nanette ^{[4
]}

Nisolle, Michelle ^{[1
,2
]}

Braun, Thorsten ^{[5
]}

Munaut, Carine ^{[2
]}

Foidart, Jean-Michel ^{[1
,2
]}

机构：

[1] Univ Liege, Hop Citadelle, Ctr Hosp Univ, Dept Obstet & Gynecol, Liege, Belgium

[2] Univ Liege, Ctr Hosp Univ, GIGA Canc, Lab Tumor & Dev Biol, Liege, Belgium

[3] Univ Buenos Aires, Sch Med, JJ Naon Morphol Inst, Buenos Aires, DF, Argentina

[4] Charite Campus Virchow Klinikum, Dept Pathol, Berlin, Germany

[5] Charite Campus Virchow Klinikum, Dept Obstet, Berlin, Germany

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2012年 / 207卷 / 03期

关键词：

placenta increta; placental bed; vessel architecture; virtual imaging; 3-DIMENSIONAL POWER DOPPLER; ACCRETA; PREVIA; QUANTIFICATION; EXPRESSION; MANAGEMENT; RECEPTORS; DIAGNOSIS; CRETA;

D O I：

10.1016/j.ajog.2012.06.083

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: The objective of the study was to characterize the vascular architecture at the placental-maternal interface in pregnancies complicated by placenta increta and normal pregnancies. STUDY DESIGN: Vessel numbers and cross-section area density and spatial and area distributions in 13 placenta-increta placental beds were compared with 9 normal placental beds using computer-assisted image analysis of whole-slide CD31 immunolabeled sections. RESULTS: The total areas occupied by vessels in normal and placentaincreta placental beds were comparable, but vessels were significantly sparser and larger in the latter. Moreover, placenta-increta-vessel distributions (area and distance from the placental-myometrial junction) were more heterogeneous. CONCLUSION: Size and spatial organization of the placenta-increta vascular architecture at the placental-maternal interface differed from normal and might partially explain the severe hemorrhage observed during placenta-increta deliveries.

引用

页码：188.e1 / 188.e9

页数：9

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