Background and Objectives Anti-calcitonin gene-related peptide (CGRP) (receptor) antibodies are approved as preventive treatment for migraine. Recent concerns have been raised after a retrospective analysis of postmarketing case reports of elevated blood pressure (BP) associated with erenumab. In this prospective follow-up study, we aimed to assess the safety regarding BP in a real-world setting. Methods All people with migraine who were treated with erenumab and fremanezumab at the Leiden Headache Center between January 2019 and January 2021 were included. BP measurements were collected from baseline (T0) until 12 months of follow-up, with a 3-month interval (T1-T4). Mixed linear models were fitted with time as a fixed effect and the patient as a random effect. Results Both systolic and diastolic BP were increased at all time points T1-T4 compared with T0 (p < 0.001). The maximum estimated increase in the mean systolic BP was 5.2 mm Hg (95% CI 3.1-7.5). The maximum estimated increase in the mean diastolic BP was 3.5 mm Hg (95% CI 2.0-4.9). In the erenumab group (n = 109), both systolic and diastolic BP were increased at all time points compared with T0 (all p < 0.001). For fremanezumab (n = 87), systolic but not diastolic BP was increased compared with T0 at T1 (p = 0.006) and T2 (p = 0.004). Four patients (3.7%) with normal BP at T0 required antihypertensive treatment after erenumab was started. Discussion The mean systolic and diastolic BP increased after anti-CGRP (receptor) antibodies were started. The majority of patients remained within the normal BP limits, but some patients required antihypertensive treatment. Physicians should be aware that people with migraine may be at risk of developing hypertension when treated with anti-CGRP (receptor) antibodies, and this should be added to (inter)national treatment guidelines. Classification of Evidence This study provides Class III evidence that anti-CGRP (receptor) antibodies increase BP when used to treat patients with migraine.
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页码:E1897 / E1904
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[1]
[Anonymous], 2018, EUR HEART J, DOI DOI 10.1093/eurheartj/ehy339
机构:
Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USAMerck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
Bigal, M. E.
;
Kurth, T.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Prevent Med, Boston, MA 02115 USAMerck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
Kurth, T.
;
Santanello, N.
论文数: 0引用数: 0
h-index: 0
机构:
Merck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USAMerck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
Santanello, N.
;
Buse, D.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USAMerck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
Buse, D.
;
Golden, W.
论文数: 0引用数: 0
h-index: 0
机构:Merck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
Golden, W.
;
Robbins, M.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USAMerck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
Robbins, M.
;
Lipton, R. B.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA
Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA
Montefiore Headache Ctr, Bronx, NY USAMerck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
机构:
Mayo Clin, Dept Neurol, Phoenix, AZ 85054 USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Dodick, David W.
;
Goadsby, Peter J.
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, NIHR Wellcome Trust Clin Res Facil, London, England
Univ Calif San Francisco, Dept Neurol, San Francisco, CA USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Goadsby, Peter J.
;
Silberstein, Stephen D.
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Neurol, Jefferson Headache Ctr, Philadelphia, PA 19107 USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Silberstein, Stephen D.
;
Lipton, Richard B.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA
Albert Einstein Coll Med, Montefiore Headache Ctr, Bronx, NY 10467 USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Lipton, Richard B.
;
Olesen, Jes
论文数: 0引用数: 0
h-index: 0
机构:
Univ Copenhagen, Fac Hlth & Med Sci, Glostrup Hosp, Danish Headache Ctr, Copenhagen, Denmark
Univ Copenhagen, Fac Hlth & Med Sci, Glostrup Hosp, Dept Neurol, Copenhagen, DenmarkMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Olesen, Jes
;
Ashina, Messoud
论文数: 0引用数: 0
h-index: 0
机构:
Univ Copenhagen, Fac Hlth & Med Sci, Glostrup Hosp, Danish Headache Ctr, Copenhagen, Denmark
Univ Copenhagen, Fac Hlth & Med Sci, Glostrup Hosp, Dept Neurol, Copenhagen, DenmarkMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Ashina, Messoud
;
Wilks, Kerri
论文数: 0引用数: 0
h-index: 0
机构:
MD Clin, Hallandale Beach, FL USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Wilks, Kerri
;
Kudrow, David
论文数: 0引用数: 0
h-index: 0
机构:
Calif Med Clin Headache, Santa Monica, CA USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Kudrow, David
;
Kroll, Robin
论文数: 0引用数: 0
h-index: 0
机构:
Womens Clin Res Ctr, Seattle, WA USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Kroll, Robin
;
Kohrman, Bruce
论文数: 0引用数: 0
h-index: 0
机构:
Miami Res Associates, South Miami, FL USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Kohrman, Bruce
;
Bargar, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Boston Clin Trials, Boston, MA USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Bargar, Robert
;
Hirman, Joe
论文数: 0引用数: 0
h-index: 0
机构:
Pacific Northwest Stat Consulting, Woodinville, WA USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Hirman, Joe
;
Smith, Jeff
论文数: 0引用数: 0
h-index: 0
机构:
Alder BioPharmaceut, Bothell, WA USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
机构:
Kings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, EnglandKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
Goadsby, Peter J.
;
Silberstein, Stephen D.
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Jefferson Headache Ctr, Philadelphia, PA 19107 USAKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
Silberstein, Stephen D.
;
Yeung, Paul P.
论文数: 0引用数: 0
h-index: 0
机构:
Teva Pharmaceut Ind Ltd, Frazer, PA USAKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
Yeung, Paul P.
;
Cohen, Joshua M.
论文数: 0引用数: 0
h-index: 0
机构:
Teva Pharmaceut Ind Ltd, Frazer, PA USAKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
Cohen, Joshua M.
;
Ning, Xiaoping
论文数: 0引用数: 0
h-index: 0
机构:
Teva Pharmaceut Ind Ltd, Frazer, PA USAKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
Ning, Xiaoping
;
Yang, Ronghua
论文数: 0引用数: 0
h-index: 0
机构:
Teva Pharmaceut Ind Ltd, Frazer, PA USAKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
Yang, Ronghua
;
Dodick, David W.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Phoenix, AZ USAKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
机构:
Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USAMerck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
Bigal, M. E.
;
Kurth, T.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Prevent Med, Boston, MA 02115 USAMerck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
Kurth, T.
;
Santanello, N.
论文数: 0引用数: 0
h-index: 0
机构:
Merck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USAMerck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
Santanello, N.
;
Buse, D.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USAMerck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
Buse, D.
;
Golden, W.
论文数: 0引用数: 0
h-index: 0
机构:Merck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
Golden, W.
;
Robbins, M.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USAMerck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
Robbins, M.
;
Lipton, R. B.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA
Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA
Montefiore Headache Ctr, Bronx, NY USAMerck Res Labs, Dept Outcomes Res, Whitehouse Stn, NJ USA
机构:
Mayo Clin, Dept Neurol, Phoenix, AZ 85054 USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Dodick, David W.
;
Goadsby, Peter J.
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, NIHR Wellcome Trust Clin Res Facil, London, England
Univ Calif San Francisco, Dept Neurol, San Francisco, CA USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Goadsby, Peter J.
;
Silberstein, Stephen D.
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Dept Neurol, Jefferson Headache Ctr, Philadelphia, PA 19107 USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Silberstein, Stephen D.
;
Lipton, Richard B.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA
Albert Einstein Coll Med, Montefiore Headache Ctr, Bronx, NY 10467 USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Lipton, Richard B.
;
Olesen, Jes
论文数: 0引用数: 0
h-index: 0
机构:
Univ Copenhagen, Fac Hlth & Med Sci, Glostrup Hosp, Danish Headache Ctr, Copenhagen, Denmark
Univ Copenhagen, Fac Hlth & Med Sci, Glostrup Hosp, Dept Neurol, Copenhagen, DenmarkMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Olesen, Jes
;
Ashina, Messoud
论文数: 0引用数: 0
h-index: 0
机构:
Univ Copenhagen, Fac Hlth & Med Sci, Glostrup Hosp, Danish Headache Ctr, Copenhagen, Denmark
Univ Copenhagen, Fac Hlth & Med Sci, Glostrup Hosp, Dept Neurol, Copenhagen, DenmarkMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Ashina, Messoud
;
Wilks, Kerri
论文数: 0引用数: 0
h-index: 0
机构:
MD Clin, Hallandale Beach, FL USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Wilks, Kerri
;
Kudrow, David
论文数: 0引用数: 0
h-index: 0
机构:
Calif Med Clin Headache, Santa Monica, CA USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Kudrow, David
;
Kroll, Robin
论文数: 0引用数: 0
h-index: 0
机构:
Womens Clin Res Ctr, Seattle, WA USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Kroll, Robin
;
Kohrman, Bruce
论文数: 0引用数: 0
h-index: 0
机构:
Miami Res Associates, South Miami, FL USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Kohrman, Bruce
;
Bargar, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Boston Clin Trials, Boston, MA USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Bargar, Robert
;
Hirman, Joe
论文数: 0引用数: 0
h-index: 0
机构:
Pacific Northwest Stat Consulting, Woodinville, WA USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
Hirman, Joe
;
Smith, Jeff
论文数: 0引用数: 0
h-index: 0
机构:
Alder BioPharmaceut, Bothell, WA USAMayo Clin, Dept Neurol, Phoenix, AZ 85054 USA
机构:
Kings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, EnglandKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
Goadsby, Peter J.
;
Silberstein, Stephen D.
论文数: 0引用数: 0
h-index: 0
机构:
Thomas Jefferson Univ, Jefferson Headache Ctr, Philadelphia, PA 19107 USAKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
Silberstein, Stephen D.
;
Yeung, Paul P.
论文数: 0引用数: 0
h-index: 0
机构:
Teva Pharmaceut Ind Ltd, Frazer, PA USAKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
Yeung, Paul P.
;
Cohen, Joshua M.
论文数: 0引用数: 0
h-index: 0
机构:
Teva Pharmaceut Ind Ltd, Frazer, PA USAKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
Cohen, Joshua M.
;
Ning, Xiaoping
论文数: 0引用数: 0
h-index: 0
机构:
Teva Pharmaceut Ind Ltd, Frazer, PA USAKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
Ning, Xiaoping
;
Yang, Ronghua
论文数: 0引用数: 0
h-index: 0
机构:
Teva Pharmaceut Ind Ltd, Frazer, PA USAKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England
Yang, Ronghua
;
Dodick, David W.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Phoenix, AZ USAKings Coll London, SLaM Biomed Res Ctr, NIHR Wellcome Trust Kings Clin Res Facil, London, England