RNA-binding proteins and post-transcriptional gene regulation

被引：1062

作者：

Glisovic, Tina ^{[1
]}

Bachorik, Jennifer L. ^{[1
]}

Yong, Jeongsik ^{[1
]}

Dreyfuss, Gideon ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Howard Hughes Med Inst, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

来源：

FEBS LETTERS | 2008年 / 582卷 / 14期

关键词：

RNA; ribonucleoprotein; RNP; RNA-binding protein; RNA processing; gene expression;

D O I：

10.1016/j.febslet.2008.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNAs in cells are associated with RNA-binding proteins (RBPs) to form ribonucleoprotein (RNP) complexes. The RBPs influence the structure and interactions of the RNAs and play critical roles in their biogenesis, stability, function, transport and cellular localization. Eukaryotic cells encode a large number of RBPs (thousands in vertebrates), each of which has unique RNA-binding activity and protein-protein interaction characteristics. The remarkable diversity of RBPs, which appears to have increased during evolution in parallel to the increase in the number of introns, allows eukaryotic cells to utilize them in an enormous array of combinations giving rise to a unique RNP for each RNA. In this short review, we focus on the RBPs that interact with pre-mRNAs and mRNAs and discuss their roles in the regulation of post-transcriptional gene expression. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1977 / 1986

页数：10

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