Histamine Stimulates Neurogenesis in the Rodent Subventricular Zone

被引：36

作者：

Bernardino, Liliana ^{[1
,2
,3
]}

Eiriz, Maria Francisca ^{[2
]}

Santos, Tiago ^{[2
]}

Xapelli, Sara ^{[2
]}

Grade, Sofia ^{[2
]}

Rosa, Alexandra Isabel ^{[2
]}

Cortes, Luisa ^{[2
]}

Ferreira, Raquel ^{[2
]}

Braganca, Jose ^{[4
]}

Agasse, Fabienne ^{[2
]}

Ferreira, Lino ^{[2
]}

Malva, Joao O. ^{[1
,2
]}

机构：

[1] Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal

[2] Univ Beira Interior, Ctr Neurosci & Cell Biol, Covilha, Portugal

[3] Univ Beira Interior, Hlth Sci Res Ctr, Covilha, Portugal

[4] Univ Algarve, Inst Biotechnol & Bioengn, Ctr Mol & Struct Biomed, Faro, Portugal

来源：

STEM CELLS | 2012年 / 30卷 / 04期

关键词：

Subventricular zone; Histamine; Biocompatible microparticles; Neuronal differentiation; EMBRYONIC STEM-CELLS; NECROSIS-FACTOR-ALPHA; NEURONAL DIFFERENTIATION; CSF HISTAMINE; PRECOLUMN DERIVATIZATION; PROMOTES NEUROGENESIS; TELE-METHYLHISTAMINE; CEREBROSPINAL-FLUID; PROGENITOR CELLS; BRAIN;

D O I：

10.1002/stem.1042

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Neural stem/progenitor cells present in the subventricular zone (SVZ) are a potential source of repairing cells after injury. Therefore, the identification of novel players that modulate neural stem cells differentiation can have a huge impact in stem cell-based therapies. Herein, we describe a unique role of histamine in inducing functional neuronal differentiation from cultured mouse SVZ stem/progenitor cells. This proneurogenic effect depends on histamine 1 receptor activation and involves epigenetic modifications and increased expression of Mash1, Dlx2, and Ngn1 genes. Biocompatible poly (lactic-co-glycolic acid) microparticles, engineered to release histamine in a controlled and prolonged manner, also triggered robust neuronal differentiation in vitro. Preconditioning with histamine-loaded microparticles facilitated neuronal differentiation of SVZ-GFP cells grafted in hippocampal slices and in in vivo rodent brain. We propose that neuronal commitment triggered by histamine per se or released from biomaterial-derived vehicles may represent a new tool for brain repair strategies. STEM CELLS 2012; 30:773784

引用

页码：773 / 784

页数：12

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