Disordered RNA chaperone proteins: from functions to disease

被引：61
作者：
Ivanyi-Nagy, R
Davidovic, L
Khandjian, EW
Darlix, JL
机构：
[1] Ecole Normale Super Lyon, Unite Virol Humaine 412, F-69364 Lyon, France
[2] INSERM, F-69364 Lyon, France
[3] Univ Laval, CHUQ, Hop St Francois Assise, Unite Rech Genet Humaine & Mol, Laval, PQ G1L 3L5, Canada
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2005年 / 62卷 / 13期
关键词：
intrinsically unstructured proteins; RNA-binding proteins; RNA chaperones; human immunodeficiency virus; NCp7; fragile X mental retardation; FMRP; prion diseases;
D O I：
10.1007/s00018-005-5100-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RNA chaperones are ubiquitous proteins that play pivotal roles in cellular RNA metabolism and RNA virus replication. Here we propose that they act by organizing complex and highly dynamic networks of RNA-RNA, RNA-protein and protein-protein interactions. How this is achieved and how their malfunction may lead to disease will be discussed through the examples of human immunodeficiency virus type 1 nucleocapsid protein (NCp7), the fragile X mental retardation protein and the prion protein.
引用
收藏
页码：1409 / 1417
页数：9
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