MICROFLUIDIC PRINT-TO-SYNTHESIS ENABLED COMBINATORIAL PEPTIDE MICROARRAY FOR CANCER TARGETING

被引：0

作者：

Li, J. ^{[1
]}

Carney, R. P. ^{[1
]}

Liu, R. ^{[1
]}

Fan, J. ^{[1
]}

Zhao, S. ^{[1
]}

Lam, K. S. ^{[1
]}

Pan, T. ^{[1
]}

机构：

[1] Univ Calif Davis, Davis, CA 95616 USA

来源：

2017 19TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS) | 2017年

关键词：

Microfluidic printing; combinatorial peptide library; PEG; microarray; cancer targeting;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

This paper reports our newly developed microfluidic print-to-screen (MPS) platform and its application for synthesizing combinatorial peptide on PEG microdisc array. The MPS platform possesses several distinct features including easy operation, free of contamination, multiplexibility, low cost, high throughput and array density. The performance of the MPS system is characterized and, as proof of concept, a tetrapeptide library was constructed with an array density of 2560 spots/slide using the MPS approach. The library was screened for ligands targeting alpha(4)beta(1) integrin overexpressed on tumor cell plasma membranes. Repeatable outcomes demonstrate the feasibility of the MPS platform, as well as identification of positive sequences that actively bind to tumor cells.

引用

页码：2195 / 2198

页数：4

共 5 条

[1] Therapeutic cancer targeting peptides [J].