The Hemetsberger-Knittel synthesis of substituted 5-, 6-, and 7-azaindoles

被引：33

作者：

Roy, PJ ^{[1
]}

Dufresne, C ^{[1
]}

Lachance, N ^{[1
]}

Leclerc, JP ^{[1
]}

Boisvert, M ^{[1
]}

Wang, ZY ^{[1
]}

Leblanc, Y ^{[1
]}

机构：

[1] Merck Frosst Ctr Therapeut Res, Pointe Claire, PQ H9R 4P8, Canada

来源：

SYNTHESIS-STUTTGART | 2005年 / 16期

关键词：

Hemetsberger-Knittel reaction; azaindoles; thermolysis; cyclization; template;

D O I：

10.1055/s-2005-872165

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of substituted 5-, 6-, and 7-azaindoles were prepared via the Hemetsberger-Knittel reaction. In general, better yields were obtained at higher temperatures and shorter reaction times than required for the formation of the analogous indoles, and in some cases, only decomposition occurred below a mininium ternperature. The resulting templates offer up to five sites for subsequent functionalization to allow a wide range of chemical diversity.

引用

页码：2751 / 2757

页数：7

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