Immunotherapy Approaches Targeting Regulatory T-Cells

被引：0

作者：

Onishi, Hideya ^{[1
]}

Morisaki, Takashi ^{[2
]}

Katano, Mitsuo ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Canc Therapy & Res, Higashi Ku, Fukuoka 8128582, Japan

[2] Fukuoka Canc Gen Clin, Fukuoka, Japan

来源：

ANTICANCER RESEARCH | 2012年 / 32卷 / 03期

关键词：

Dendritic cells; CD4+T-cell; Treg; immunotherapy; regulatory T-cells; review; PERIPHERAL-BLOOD; CANCER PATIENTS; LUNG-CANCER; NKT CELLS; TGF-BETA; GAMMA; SUPPRESSION; EXPRESSION; PROGNOSIS; EXOSOMES;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The immune system prevents establishment and progression of cancer through innate and adaptive surveillance. However, some cancerous cells successfully evade the immune system. Regulatory, T-cells (Tregs) facilitate such evasion. Tregs may be the factor responsible for the limited success of human tumor immunotherapy to date. To improve immunotherapy, it is thought that the number of Tregs and their functions should be inhibited in patients with advanced cancer. In this review, we focus on recent immunotherapy efforts targeting Tregs.

引用

页码：997 / 1003

页数：7

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