Engineered T cells: the promise and challenges of cancer immunotherapy

被引：806

作者：

Fesnak, Andrew D. ^{[1
]}

June, Carl H.

Levine, Bruce L. ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS CANCER | 2016年 / 16卷 / 09期

基金：

美国国家卫生研究院;

关键词：

CHIMERIC ANTIGEN RECEPTOR; CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; GLIOBLASTOMA STEM-CELLS; B-CELL; ANTITUMOR-ACTIVITY; ADOPTIVE TRANSFER; MULTIPLE-MYELOMA; MONOCLONAL-ANTIBODY; GENE-TRANSFER;

D O I：

10.1038/nrc.2016.97

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The immune system evolved to distinguish non-self from self to protect the organism. As cancer is derived from our own cells, immune responses to dysregulated cell growth present a unique challenge. This is compounded by mechanisms of immune evasion and immunosuppression that develop in the tumour microenvironment. The modern genetic toolbox enables the adoptive transfer of engineered T cells to create enhanced anticancer immune functions where natural cancer-specific immune responses have failed. Genetically engineered T cells, so-called 'living drugs', represent a new paradigm in anticancer therapy. Recent clinical trials using T cells engineered to express chimeric antigen receptors (CARs) or engineered T cell receptors (TCRs) have produced stunning results in patients with relapsed or refractory haematological malignancies. In this Review we describe some of the most recent and promising advances in engineered T cell therapy with a particular emphasis on what the next generation of T cell therapy is likely to entail.

引用

页码：566 / 581

页数：16

共 239 条

[51] Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics [J].

Crompton, Joseph G. ;

Sukumar, Madhusudhanan ;

Roychoudhuri, Rahul ;

Clever, David ;

Gros, Alena ;

Eil, Robert L. ;

Eric Tran ;

Hanada, Ken-ichi ;

Yu, Zhiya ;

Palmer, Douglas C. ;

Kerkar, Sid P. ;

Michalek, Ryan D. ;

Upham, Trevor ;

Leonardi, Anthony ;

Acquavella, Nicolas ;

Wang, Ena ;

Marincola, Francesco M. ;

Gattinoni, Luca ;

Muranski, Pawel ;

Sundrud, Mark S. ;

Klebanoff, Christopher A. ;

Rosenberg, Steven A. ;

Fearon, Douglas T. ;

Restifo, Nicholas P. .

CANCER RESEARCH, 2015, 75 (02) :296-305

[52] Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study [J].

Cruz, Conrad Russell Y. ;

Micklethwaite, Kenneth P. ;

Savoldo, Barbara ;

Ramos, Carlos A. ;

Lam, Sharon ;

Ku, Stephanie ;

Diouf, Oumar ;

Liu, Enli ;

Barrett, A. John ;

Ito, Sawa ;

Shpall, Elizabeth J. ;

Krance, Robert A. ;

Kamble, Rammurti T. ;

Carrum, George ;

Hosing, Chitra M. ;

Gee, Adrian P. ;

Mei, Zhuyong ;

Grilley, Bambi J. ;

Heslop, Helen E. ;

Rooney, Cliona M. ;

Brenner, Malcolm K. ;

Bollard, Catherine M. ;

Dotti, Gianpietro .

BLOOD, 2013, 122 (17) :2965-2973

[53] Multi-Center Clinical Trial of CAR T Cells in Pediatric/Young Adult Patients with Relapsed B-Cell ALL [J].

Curran, Kevin J. ;

Riviere, Isabelle ;

Silverman, Lewis B. ;

Kobos, Rachel ;

Shukla, Neerav ;

Steinherz, Peter G. ;

Boulad, Farid ;

Prockop, Susan ;

Scaradavou, Andromachi ;

Margossian, Steven P. ;

Wang, Xiuyan ;

Wang, Yongzeng ;

Szenes, Victoria ;

Dansereau, Colleen H. ;

MacKinnon, Brenda ;

Sauter, Craig S. ;

Park, Jae H. ;

Kernan, Nancy A. ;

O'Reilly, Richard J. ;

Sadelain, Michel ;

Brentjens, Renier J. .

BLOOD, 2015, 126 (23)

[54] CD19 Targeted Allogeneic EBV-Specific T Cells for the Treatment of Relapsed ALL in Pediatric Patients Post HSCT [J].

Curran, Kevin J. ;

Kernan, Nancy A. ;

Wang, Xiuyan ;

Taylor, Clare ;

Doubrovina, Ekaterina ;

Bartido, Shirley ;

Sadelain, Michel ;

O'Reilly, Richard J. ;

Brentjens, Renier J. ;

Riviere, Isabelle .

BLOOD, 2012, 120 (21)

[55] Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia [J].

Dai, Hanren ;

Zhang, Wenying ;

Li, Xiaolei ;

Han, Qingwang ;

Guo, Yelei ;

Zhang, Yajing ;

Wang, Yao ;

Wang, Chunmeng ;

Shi, Fengxia ;

Zhang, Yan ;

Chen, Meixia ;

Feng, Kaichao ;

Wang, Quanshun ;

Zhu, Hongli ;

Fu, Xiaobing ;

Li, Suxia ;

Han, Weidong .

ONCOIMMUNOLOGY, 2015, 4 (11)

[56] Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy [J].

DaneshManesh, Amir H. ;

Mikaelsson, Eva ;

Jeddi-Tehrani, Mahmood ;

Bayat, Ali Ahmad ;

Ghods, Roya ;

Ostadkarampour, Mahyar ;

Akhondi, Mehdi ;

Lagercrantz, Svetlana ;

Larsson, Catharina ;

Osterborg, Anders ;

Shokri, Fazel ;

Mellstedt, Hakan ;

Rabbani, Hodjattallah .

INTERNATIONAL JOURNAL OF CANCER, 2008, 123 (05) :1190-1195

[57] Targeting the Intracellular WT1 Oncogene Product with a Therapeutic Human Antibody [J].

Dao, Tao ;

Yan, Su ;

Veomett, Nicholas ;

Pankov, Dmitry ;

Zhou, Liang ;

Korontsvit, Tatyana ;

Scott, Andrew ;

Whitten, Joseph ;

Maslak, Peter ;

Casey, Emily ;

Tan, Taochao ;

Liu, Hong ;

Zakhaleva, Victoria ;

Curcio, Michael ;

Doubrovina, Ekaterina ;

O'Reilly, Richard J. ;

Liu, Cheng ;

Scheinberg, David A. .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (176)

[58] Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia [J].

Davila, Marco L. ;

Riviere, Isabelle ;

Wang, Xiuyan ;

Bartido, Shirley ;

Park, Jae ;

Curran, Kevin ;

Chung, Stephen S. ;

Stefanski, Jolanta ;

Borquez-Ojeda, Oriana ;

Olszewska, Malgorzata ;

Qu, Jinrong ;

Wasielewska, Teresa ;

He, Qing ;

Fink, Mitsu ;

Shinglot, Himaly ;

Youssif, Maher ;

Satter, Mark ;

Wang, Yongzeng ;

Hosey, James ;

Quintanilla, Hilda ;

Halton, Elizabeth ;

Bernal, Yvette ;

Bouhassira, Diana C. G. ;

Arcila, Maria E. ;

Gonen, Mithat ;

Roboz, Gail J. ;

Maslak, Peter ;

Douer, Dan ;

Frattini, Mark G. ;

Giralt, Sergio ;

Sadelain, Michel ;

Brentjens, Renier .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

[59] Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells [J].

De Palma, M ;

Montini, E ;

Santoni de Sio, FR ;

Benedicenti, F ;

Gentile, A ;

Medico, E ;

Naldini, L .

BLOOD, 2005, 105 (06) :2307-2315

[60] Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations [J].

Deniger, Drew C. ;

Yu, Jianqiang ;

Huls, M. Helen ;

Figliola, Matthew J. ;

Mi, Tiejuan ;

Maiti, Sourindra N. ;

Widhopf, George F. ;

Hurton, Lenka V. ;

Thokala, Radhika ;

Singh, Harjeet ;

Olivares, Simon ;

Champlin, Richard E. ;

Wierda, William G. ;

Kipps, Thomas J. ;

Cooper, Laurence J. N. .

PLOS ONE, 2015, 10 (06)

← 1 2 3 4 5 6 7 8 9 10 →