The bimanual ovarian palpation examination in the Prostate, Lung, Colorectal and Ovarian cancer screening trial: Performance and complications

被引:12
作者
Doroudi, Maryam [1 ]
Kramer, Barnett S. [1 ]
Pinsky, Paul F. [1 ]
机构
[1] NIH, Canc Prevent Div, 9609 Med Ctr Dr, Bethesda, MD 20892 USA
关键词
Prostate; Lung; Colorectal and Ovarian cancer screening trial; bimanual ovarian palpation; ovarian cancer; sensitivity; specificity; negative predictive value; positive predictive value; complications; MORTALITY;
D O I
10.1177/0969141316680381
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objective: To provide evidence about the performance characteristics and consequences of bimanual ovarian palpation. Setting and methods: The Prostate, Lung, Colorectal and Ovarian cancer screening trial randomized 154,900 individuals to either an intervention or control arm. Enrolled eligible participants were aged 55-74, had no history of trial cancers, and no current treatment for cancer. Intervention arm women received CA-125 tests and transvaginal ultrasound. Bimanual ovarian palpation was offered annually during the first four years of the trial. Bimanual ovarian palpation-specific sensitivity and specificity were calculated, as were rates of diagnostic procedures and resulting complications following positive bimanual ovarian palpation screens. Results: A total of 20,872 women received at least one bimanual ovarian palpation, with 50,498 total bimanual ovarian palpation examinations performed. The sensitivity and specificity of bimanual ovarian palpation were 5.1% (2/39) and 99.0% (49,957/50,459), respectively; no cases were detected by bimanual ovarian palpation alone. Rates for most follow-up procedures for abnormal results in women without ovarian cancer were higher among the group with another screening test positive, except for pelvic exam, where rates were similar. No complications were reported in the bimanual ovarian palpation-only positive group. Conclusion: Low sensitivity of bimanual ovarian palpation alone and in combination with other tests argue against using bimanual ovarian palpation as a screening test for ovarian cancer in asymptomatic women.
引用
收藏
页码:220 / 222
页数:3
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