Genetic subtypes of HIV type 1 viruses circulating in the Czech Republic

被引：12
作者：
Reinis, M
Brucková, M
Graham, RR
Vandasová, J
Stanková, M
Carr, JK
机构：
[1] Natl Inst Publ Hlth, Natl Reference Lab AIDS, Prague 10042 10, Czech Republic
[2] USN, Virol Res Program, Med Res Unit 3, Cairo, Egypt
[3] Bulovka Hosp, AIDS Ctr, Prague 18081 8, Czech Republic
[4] Henry M Jackson Fdn, Rockville, MD USA
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2001年 / 17卷 / 13期
关键词：
D O I：
10.1089/088922201750461384
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We analyzed the genetic diversity of HIV-1 strains circulating in the Czech Republic. Phylogenetic analysis of the env and gag gene sequence fragments from 39 isolates revealed that the majority of these strains (32 of 39, 82%) were of subtype B; other genetic subtypes identified were A, C, F, and recombinant circulating form CRF01_AE. The isolates that did not cluster with subtype B originated almost exclusively from a heterosexual route of transmission. The molecular epidemiological data are suggestive of multiple entry of HIV-1 infection into the Czech Republic and show that the genetic pattern of the HIV-1 strains circulating in this country corresponds to that found in other European countries.
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页码：1305 / 1310
页数：6
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