Plasmablastic lymphoma of the oral cavity in an HIV-negative patient

被引:11
作者
Guan, Bing [1 ]
Zhang, Xinhua [1 ]
Hu, Weidong [2 ]
Rao, Qiu [1 ]
Wang, Yan [1 ]
Zhu, Yun [1 ]
Wang, Hai
Ma, Henhui
Zhou, Hanbo
Zhou, Xiaojun [1 ]
机构
[1] Nanjing Univ, Dept Pathol, Sch Med, Nanjing Jinling Hosp, Nanjing 210002, Peoples R China
[2] Huang Shi Inst Technol, Sch Med, Dept Clin Lab, Huangshi 435003, Peoples R China
关键词
Plasmablastic lymphoma; Immunohistochemistry; In situ hybridization; Gene rearrange; HUMAN-IMMUNODEFICIENCY-VIRUS; EXPRESSION; DISEASE; ENTITY;
D O I
10.1016/j.anndiagpath.2010.05.011
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Plasmablastic lymphoma (PBL) is a rare, highly aggressive lymphoma typified by immunoblast-like cells with abundant basophilic cytoplasm and paranuclear hof. It shows absent expression of CD45 and CD20. In contrast, it displays a constant reaction with CD 138 and VS38c. It may be easily misinterpreted as some other lymphoma. An exhaustive integration of clinical, morphologic, phenotypic, and molecular features is important to exclude misdiagnosis and inappropriate treatment. We report a case of HIV-negative PBL arising on the left areas of posterior teeth mucosa of a 58-year-old man. Immunohistochemically, the tumor cell was immunoreactive for CD138, VS38c, VEGF, and vimentin; Ki-67 showed a high proliferation rate. Epstein-Barr virus (in situ hybridization) was nonreactive, and IgH gene rearrangement was identified by polymerase chain reaction amplification products. A diagnosis of PBL was rendered. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:436 / 440
页数:5
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