Investigation of a weak magnetic field effect on the in vitro catalytic activity of adenosine deaminase and xanthine oxidase

被引:1
作者
Batcioglu, Kadir [1 ]
Dogan, Metin [2 ]
Uyumlu, Ayse B. [1 ]
Satilmis, Basri [1 ]
Bayri, Nevzat [3 ]
Atalay, Selcuk [3 ]
Demirtas, Hakan [4 ]
机构
[1] Univ Inonu, Dept Biochem, Fac Pharm, Malatya, Turkey
[2] Univ Inonu, Dept Radiol, Fac Med, Malatya, Turkey
[3] Univ Inonu, Dept Phys, Fac Art & Sci, Malatya, Turkey
[4] Univ Illinois, Dept Epidemiol & Biostat, Chicago, IL USA
关键词
Magnetic field; Adenosine deaminase; Xanthine oxidase; EXPOSURE; CELLS; LEUKEMIA;
D O I
10.4149/gpb_2011_04_410
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effect of a weak magnetic field (MF) on adenosine deaminase (ADA) and xanthine oxidase (XOD) activities have been investigated. A 50 Hz uniform MF was generated, and the magnitude of the field was kept constant at 5.8 mT. The changes in ADA activity over time were significantly different in and out of the MF; MF caused a steeper decline in ADA activity compared to the situation when no MF is present. In addition, MF caused a significant increase in XOD activity. There were no significant time-related changes for either enzyme in the absence of the MF. We suggest that a weak MF affects enzymatic systems.
引用
收藏
页码:410 / 414
页数:5
相关论文
共 20 条
[1]  
Batcioglu Kadir, 2002, Journal of Biological Physics and Chemistry, V2, P108
[2]  
Berg J.M., 2007, Biochemistry, V6th
[3]   Acute leukemia in electrical workers: a New Zealand case-control study [J].
Bethwaite, P ;
Cook, A ;
Kennedy, J ;
Pearce, N .
CANCER CAUSES & CONTROL, 2001, 12 (08) :683-689
[4]   DEDUCED AMINO-ACID-SEQUENCE OF ESCHERICHIA-COLI ADENOSINE-DEAMINASE REVEALS EVOLUTIONARILY CONSERVED AMINO-ACID-RESIDUES - IMPLICATIONS FOR CATALYTIC FUNCTION [J].
CHANG, Z ;
NYGAARD, P ;
CHINAULT, AC ;
KELLEMS, RE .
BIOCHEMISTRY, 1991, 30 (08) :2273-2280
[5]   Static magnetic field therapy: Dosimetry considerations [J].
Colbert, Agatha P. ;
Markov, Marko S. ;
Souder, James S. .
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2008, 14 (05) :577-582
[6]   EFFECTS OF TIME-VARYING UNIFORM MAGNETIC-FIELDS ON NATURAL-KILLER-CELL ACTIVITY AND ANTIBODY-RESPONSE IN MICE [J].
DESEZE, R ;
BOUTHET, C ;
TUFFET, S ;
DESCHAUX, P ;
CARISTAN, A ;
MOREAU, JM ;
VEYRET, B .
BIOELECTROMAGNETICS, 1993, 14 (05) :405-412
[7]   Properties of xanthine dehydrogenase variants from rosy mutant strains of Drosophila melanogaster and their relevance to the enzyme's structure and mechanism [J].
Doyle, WA ;
Burke, JF ;
Chovnick, A ;
Dutton, FL ;
Whittle, JRS ;
Bray, RC .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 239 (03) :782-795
[8]   INVIVO ENZYME CONTROL THROUGH A STRONG STATIONARY MAGNETIC-FIELD - THE CASE OF THYMIDINE KINASE IN MOUSE BONE-MARROW CELLS [J].
FEINENDEGEN, LE ;
MUHLENSIEPEN, H .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1987, 52 (03) :469-479
[9]  
Guisti, 1984, Methods of enzymatic analysis, V2nd, P315
[10]   Occupational exposure to extremely low frequency magnetic fields and mortality from cardiovascular disease [J].
Håkansson, N ;
Gustavsson, P ;
Sastre, A ;
Floderus, B .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2003, 158 (06) :534-542