After-discharges and seizures during pediatric extra-operative electrical cortical stimulation functional brain mapping: Incidence, thresholds, and determinants

被引:34
作者
Aungaroon, Gewalin [1 ]
Vera, Alonso Zea [1 ]
Horn, Paul S. [1 ,2 ]
Byars, Anna W. [1 ]
Greiner, Hansel M. [1 ]
Tenney, Jeffrey R. [1 ]
Arthur, Todd M. [1 ]
Crone, Nathan E. [3 ]
Holland, Katherine D. [1 ]
Mangano, Francesco T. [4 ]
Arya, Ravindra [1 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Comprehens Epilepsy Ctr, Div Neurol, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp Med Ctr, Div Epidemiol & Biostat, Cincinnati, OH 45229 USA
[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[4] Cincinnati Childrens Hosp Med Ctr, Div Pediat Neurosurg, Cincinnati, OH 45229 USA
关键词
Cortical stimulation mapping; Functional brain mapping; Epilepsy surgery; Current thresholds; DRUG-RESISTANT EPILEPSY; TEMPORAL-LOBE EPILEPSY; SEX-DIFFERENCES; LOCALIZATION; CHILDREN; CORTEX;
D O I
10.1016/j.clinph.2017.06.259
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: This study examined the incidence, thresholds, and determinants of electrical cortical stimulation (ECS)-induced after-discharges (ADs) and seizures.& para;& para;Methods: Electrocorticograph recordings were reviewed to determine incidence of ECS-induced ADs and seizures. Multivariable analyses for predictors of AD/seizure occurrence and their thresholds were performed.& para;& para;Results: In 122 patients, the incidence of ADs and seizures was 77% (94/122) and 35% (43/122) respectively. Males (odds ratio [OR] 2.92, 95% CI 1.21-7.38, p = 0.02) and MRI-negative patients (OR 3.69, 95% CI 1.24-13.7, p = 0.03) were found to have higher odds of ECS-induced ADs. A significant trend for decreasing AD thresholds with age was seen (regression co-efficient -0.151, 95% Cl -0.267 to -0.035, p = 0.011 ). ECS-induced seizures were more likely in patients with lateralized functional imaging (OR 6.62, 95% Cl 1.36- 55.56, p = 0.036, for positron emission tomography) and presence of ADs (OR 3.50, 95% Cl 1.12-13.36, p = 0.043).& para;& para;Conclusions: ECS is associated with a high incidence of ADs and seizures. With age, current thresholds decrease and the probability for AD/seizure occurrence increases.& para;& para;Significance: ADs and seizures during ECS brain mapping are potentially hazardous and affect its functional validity. Thus, safer method(s) for brain mapping with improved neurophysiologic validity are desirable. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:2078 / 2086
页数:9
相关论文
共 22 条
[1]   NEW LOOK AT STATISTICAL-MODEL IDENTIFICATION [J].
AKAIKE, H .
IEEE TRANSACTIONS ON AUTOMATIC CONTROL, 1974, AC19 (06) :716-723
[2]  
[Anonymous], 1974, Electroencephalogr Clin Neurophysiol, V37, P538
[3]   Presurgical language localization with visual naming associated ECoG high- gamma modulation in pediatric drug-resistant epilepsy [J].
Arya, Ravindra ;
Wilson, J. Adam ;
Fujiwara, Hisako ;
Rozhkov, Leonid ;
Leach, James L. ;
Byars, Anna W. ;
Greiner, Hansel M. ;
Vannest, Jennifer ;
Buroker, Jason ;
Milsap, Griffin ;
Ervin, Brian ;
Minai, Ali ;
Horn, Paul S. ;
Holland, Katherine D. ;
Mangano, Francesco T. ;
Crone, Nathan E. ;
Rose, Douglas F. .
EPILEPSIA, 2017, 58 (04) :663-673
[4]   Clinical factors predict surgical outcomes in pediatric MRI-negative drug-resistant epilepsy [J].
Arya, Ravindra ;
Leach, James L. ;
Horn, Paul S. ;
Greiner, Hansel M. ;
Gelfand, Michael ;
Byars, Anna W. ;
Arthur, Todd M. ;
Tenney, Jeffrey R. ;
Jain, Sejal V. ;
Rozhkov, Leonid ;
Fujiwara, Hisako ;
Rose, Douglas F. ;
Mangano, Francesco T. ;
Holland, Katherine D. .
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2016, 41 :56-61
[5]   BRAIN MAPPING TECHNIQUES TO MAXIMIZE RESECTION, SAFETY, AND SEIZURE CONTROL IN CHILDREN WITH BRAIN-TUMORS [J].
BERGER, MS ;
KINCAID, J ;
OJEMANN, GA ;
LETTICH, E .
NEUROSURGERY, 1989, 25 (05) :786-792
[6]   Properties of after-discharges from cortical electrical stimulation in focal epilepsies [J].
Blume, WT ;
Jones, DC ;
Pathak, P .
CLINICAL NEUROPHYSIOLOGY, 2004, 115 (04) :982-989
[7]   Magnetic resonance imaging negative positron emission tomography positive temporal lobe epilepsy: FDG-PET pattern differs from mesial temporal lobe epilepsy [J].
Carne, R. P. ;
Cook, M. J. ;
MacGregor, L. R. ;
Kilpatrick, C. J. ;
Hicks, R. J. ;
O'Brien, T. J. .
MOLECULAR IMAGING AND BIOLOGY, 2007, 9 (01) :32-42
[8]   MRI-negative PET-positive' temporal lobe epilepsy (TLE) and mesial TLE differ with quantitative MRI and PET: a case control study [J].
Carne, Ross P. ;
O'Brien, Terence J. ;
Kilpatrick, Christine J. ;
MacGregor, Lachlan R. ;
Litewka, Lucas ;
Hicks, Rodney J. ;
Cook, Mark J. .
BMC NEUROLOGY, 2007, 7 (1)
[9]   Extraoperative cortical stimulation of motor function in children [J].
Chitoku, S ;
Otsubo, H ;
Harada, Y ;
Jay, V ;
Rutka, JT ;
Weiss, SK ;
Abdoll, M ;
Snead, OC .
PEDIATRIC NEUROLOGY, 2001, 24 (05) :344-350
[10]   High-frequency gamma oscillations and human brain mapping with electrocorticography [J].
Crone, Nathan E. ;
Sinai, Alon ;
Korzeniewska, Anna .
EVENT-RELATED DYNAMICS OF BRAIN OSCILLATIONS, 2006, 159 :275-295