Synthesis of Halogenated Diphenylpiperazines from L-Tyrosine Derivatives by Biotransformation

被引：0

作者：

Bao, Shumin ^{[1
,3
]}

Zhong, Xiaoyan ^{[1
,3
]}

Wan, Ying ^{[1
,3
]}

Tan, Guishan ^{[1
,2
]}

Xu, Kangping ^{[1
,3
]}

Yu, Xia ^{[1
,3
]}

机构：

[1] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Changsha 410008, Peoples R China

[3] Cent South Univ, Hunan Key Lab Diagnost & Therapeut Drug Res Chron, Changsha 410013, Peoples R China

来源：

CHEMISTRY LETTERS | 2022年 / 51卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Halogenated diphenylpiperazines; Biotransformation; L-Tyrosine; BIOSYNTHESIS;

D O I：

10.1246/cl.210551

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Piperazine-containing compounds tend to exhibit good biological activities. In this study, four novel halogenated diphenylpiperazines were biosynthesized in one step by feeding halogenated L-tyrosine derivatives to Escherichia coli cells expressing heterologous non-ribosomal peptide synthetase HqlA and short-chain reductase HqlB. The work showed potential for synthesis of halogenated diphenylpiperazines using engineered microorganism.

引用

页码：13 / 15

页数：3

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