ADIPOQ, ADIPOR1, and ADIPOR2 Polymorphisms in Relation to Serum Adiponectin Levels and BMI in Black and White Women

被引:32
作者
Cohen, Sarah S. [1 ,2 ]
Gammon, Marilie D. [1 ]
North, Kari E. [1 ,3 ]
Millikan, Robert C. [1 ]
Lange, Ethan M. [4 ,5 ]
Williams, Scott M. [6 ]
Zheng, Wei [7 ]
Cai, Qiuyin [7 ]
Long, Jirong [7 ]
Smith, Jeffrey R. [8 ]
Signorello, Lisa B. [2 ,7 ]
Blot, William J. [2 ,7 ]
Matthews, Charles E. [9 ]
机构
[1] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27515 USA
[2] Int Epidemiol Inst, Rockville, MD USA
[3] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC USA
[4] Univ N Carolina, Dept Genet, Chapel Hill, NC USA
[5] Univ N Carolina, Dept Biostat, Chapel Hill, NC USA
[6] Vanderbilt Univ, Dept Mol Physiol & Biophys, Sch Med, Nashville, TN 37232 USA
[7] Vanderbilt Univ, Dept Med, Div Epidemiol,Vanderbilt Ingram Cancer Ctr, Vanderbilt Epidemiol Ctr,Sch Med, Nashville, TN USA
[8] Vanderbilt Univ, Dept Med, Sch Med, Nashville, TN USA
[9] NCI, Nutr Epidemiol Branch, Rockville, MD USA
关键词
GENOME-WIDE ASSOCIATION; APM1; GENE; CARDIOVASCULAR-DISEASE; QUANTITATIVE TRAITS; INSULIN-RESISTANCE; HEALTHY CAUCASIANS; METABOLIC SYNDROME; HERITAGE FAMILY; IRAS FAMILY; OBESITY;
D O I
10.1038/oby.2010.346
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Adiponectin is an adipose-secreted protein with influence on several physiologic pathways including those related to insulin sensitivity, inflammation, and atherogenesis. Adiponectin levels are highly heritable and several single-nucleotide polymorphisms (SNPs) in adiponectin-related genes (ADIPOQ, ADIPOR1, ADIPOR2) have been examined in relation to circulating adiponectin levels and obesity phenotypes, but despite differences in adiponectin levels and obesity prevalence by race, few studies have included black participants. Using cross-sectional interview data and blood samples collected from 990 black and 977 white women enrolled in the Southern Community Cohort Study (SCCS) from 2002 to 2006, we examined 25 SNPs in ADIPOQ, 19 in ADIPOR1, and 27 in ADIPOR2 in relation to serum adiponectin levels and BMI using race-stratified linear regression models adjusted for age and percentage African ancestry. SNP rs17366568 in ADIPOQ was significantly associated with serum adiponectin levels in white women only (adjusted mean adiponectin levels = 15.9 for G/G genotype, 13.7 for A/G, and 9.3 for A/A, P = 0.00036). No other SNPs were associated with adiponectin or BMI among blacks or whites. Because adiponectin levels as well as obesity are highly heritable and vary by race but associations with polymorphisms in the ADIPOQ, ADIPOR1, and ADIPOR2 genes have been few in this and other studies, future work including large populations from diverse racial groups is needed to detect additional genetic variants that influence adiponectin and BMI.
引用
收藏
页码:2053 / 2062
页数:10
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