IL-6 Muscles In on the Gut and Pancreas to Enhance Insulin Secretion

被引：17

作者：

Allen, Tamara L. ^{[1
]}

Whitham, Martin ^{[1
]}

Febbraio, Mark A. ^{[1
]}

机构：

[1] Baker IDI Heart & Diabet Inst, Cellular & Mol Metab Lab, Melbourne, Vic 3008, Australia

来源：

CELL METABOLISM | 2012年 / 15卷 / 01期

关键词：

GLUCOSE-HOMEOSTASIS; INTERLEUKIN-6; DOES/DOES; SKELETAL-MUSCLE; BENEFICIAL ROLE; SENSITIVITY; OXIDATION; EXERCISE; HUMANS;

D O I：

10.1016/j.cmet.2011.12.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of the cytokine interleukin-6 (IL-6) in metabolic homeostasis is the subject of conjecture. Recent work in Nature Medicine (Ellingsgaard et al., 2011) demonstrates that IL-6 released from skeletal muscle during exercise mediates crosstalk between insulin-sensitive tissues, intestinal L cells, and pancreatic islets to adapt to changes in insulin demand.

引用

页码：8 / 9

页数：2

共 10 条

[1] Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase [J].

Carey, Andrew L. ;

Steinberg, Gregory R. ;

Macaulay, S. Lance ;

Thomas, Walter G. ;

Holmes, Anna G. ;

Ramm, Georg ;

Prelovsek, Oja ;

Hohnen-Behrens, Cordula ;

Watt, Matthew J. ;

James, David E. ;

Kemp, Bruce E. ;

Pedersen, Bente K. ;

Febbraio, Mark A. .

DIABETES, 2006, 55 (10) :2688-2697

[2] Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells [J].

Ellingsgaard, Helga ;

Hauselmann, Irina ;

Schuler, Beat ;

Habib, Abdella M. ;

Baggio, Laurie L. ;

Meier, Daniel T. ;

Eppler, Elisabeth ;

Bouzakri, Karim ;

Wueest, Stephan ;

Muller, Yannick D. ;

Hansen, Ann Maria Kruse ;

Reinecke, Manfred ;

Konrad, Daniel ;

Gassmann, Max ;

Reimann, Frank ;

Halban, Philippe A. ;

Gromada, Jesper ;

Drucker, Daniel J. ;

Gribble, Fiona M. ;

Ehses, Jan A. ;

Donath, Marc Y. .

NATURE MEDICINE, 2011, 17 (11) :1481-U1500

[3] Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction [J].

Febbraio, MA ;

Hiscock, N ;

Sacchetti, M ;

Fischer, CP ;

Pedersen, BK .

DIABETES, 2004, 53 (07) :1643-1648

[4] Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice [J].

Klover, PJ ;

Zimmers, TA ;

Koniaris, LG ;

Mooney, RA .

DIABETES, 2003, 52 (11) :2784-2789

[5] Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis - Counterpoint: Interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis [J].

Mooney, Robert A. .

JOURNAL OF APPLIED PHYSIOLOGY, 2007, 102 (02) :816-818

[6] Muscle as an endocrine organ: Focus on muscle-derived interleukin-6 [J].

Pedersen, Bente K. ;

Febbraio, Mark A. .

PHYSIOLOGICAL REVIEWS, 2008, 88 (04) :1379-1406

[7] Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis - Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis [J].

Pedersen, Bente K. ;

Febbraio, Mark A. .

JOURNAL OF APPLIED PHYSIOLOGY, 2007, 102 (02) :814-816

[8] Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6 [J].

Steensberg, A ;

van Hall, G ;

Osada, T ;

Sacchetti, M ;

Saltin, B ;

Pedersen, BK .

JOURNAL OF PHYSIOLOGY-LONDON, 2000, 529 (01) :237-242

[9] Interleukin-6 stimulates lipolysis and fat oxidation in humans [J].

van Hall, G ;

Steensberg, A ;

Sacchetti, M ;

Fischer, C ;

Keller, C ;

Schjerling, P ;

Hiscock, N ;

Moller, K ;

Saltin, B ;

Febbraio, MA ;

Pedersen, BK .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (07) :3005-3010

[10] Insulin signaling and insulin sensitivity after exercise in human skeletal muscle [J].

Wojtaszewski, JFP ;

Hansen, BF ;

Gade, J ;

Kiens, B ;

Markuns, JF ;

Goodyear, LJ ;

Richter, EA .

DIABETES, 2000, 49 (03) :325-331

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