Evolution of DNA polymerase ι structure and function in eukaryotes

被引：5

作者：

Makarova, A. V. ^{[1
]}

Tarantul, V. Z. ^{[1
]}

Gening, L. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2008年 / 73卷 / 03期

关键词：

DNA polymerase iota; error-prone activity; hypermutagenesis;

D O I：

10.1134/S0006297908030176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of DNA polymerase iota (Pol iota) enzymic activity in different classes of eukaryotes has shown that error-prone activity of this enzyme can be found only in mammals, and that it is completely absent from organisms that are at lower stages of development. It was supposed that the emergence of the error-prone Pol iota activity in mammals is caused by structural alteration of the active center. Possible functions of error-prone Pot iota in higher eukaryotes are discussed.

引用

页码：346 / 352

页数：7

共 30 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[2]

[Anonymous], 2005, EVOLUTIONARY IMMUNOL

[3] 5′-Deoxyribose phosphate lyase activity of human DNA polymerase ι in vitro [J].

Bebenek, K ;

Tissier, A ;

Frank, EG ;

McDonald, JP ;

Prasad, R ;

Wilson, SH ;

Woodgate, R ;

Kunkel, TA .

SCIENCE, 2001, 291 (5511) :2156-2159

[4] Induction of somatic mutation in a human B cell line in vitro [J].

Denepoux, S ;

Razanajaona, D ;

Blanchard, D ;

Meffre, G ;

Capra, JD ;

Banchereau, J ;

Lebecque, S .

IMMUNITY, 1997, 6 (01) :35-46

[5] ANTIBODY DIVERSITY IN LOWER-VERTEBRATES - WHY IS IT SO RESTRICTED [J].

DUPASQUIER, L .

NATURE, 1982, 296 (5855) :311-313

[6]

DUPASQUIER L, 1997, FUNDAMENTAL IMMUNOLO

[7] Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota [J].

Faili, A ;

Aoufouchi, S ;

Flatter, E ;

Guéranger, Q ;

Reynaud, CA ;

Weill, JC .

NATURE, 2002, 419 (6910) :944-947

[8] Involvement of DNA polymerase iota in hypermutagenesis and tumorigenesis: An improper model can lead to inaccurate results [J].

Gening, L. V. ;

Tarantul, V. Z. .

IMMUNOLOGY LETTERS, 2006, 106 (02) :198-199

[9] A false note of DNA polymerase iota in the choir of genome caretakers in mammals [J].

Gening, LV ;

Makarova, AV ;

Malashenko, AM ;

Tarantul, VZ .

BIOCHEMISTRY-MOSCOW, 2006, 71 (02) :155-159

[10] DNA polymerase iota-like activity in crude cell extracts of different mouse organs [J].

Gening, LV ;

Petrochenkov, AN ;

Reshetnyak, AB ;

Andreeva, LE ;

Tarantul, VZ .

BIOCHEMISTRY-MOSCOW, 2004, 69 (04) :435-440

← 1 2 3 →