Design of novel bone-targeting chemical groups and their exploitation in the discovery of anti-resorptive Src tyrosine kinase inhibitors.

被引:0
|
作者
Dalgarno, D
Pradeepan, S
Yuan, R
Bogus, J
Wardwell, S
Xing, L
Ram, M
Liou, S
Keats, J
Narula, S
Metcalf, C
Wang, Y
Keenan, T
Sundaramoorthi, R
Shakespeare, W
Sebesta, C
Bohacek, R
van Schravendijk, MR
Boyce, B
Iuliucci, J
Weigele, M
Sawyer, T
机构
[1] ARIAD Pharmaceut Inc, Cambridge, MA 02139 USA
[2] Univ Rochester, Med Ctr, Rochester, NY 14642 USA
[3] Primedica, Worcester, MA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:S507 / S507
页数:1
相关论文
共 39 条
  • [31] Design and discovery of novel monastrol-1,3,5-triazines as potent anti-breast cancer agent via attenuating Epidermal Growth Factor Receptor tyrosine kinase
    Jitendra Kumar Srivastava
    Girinath G. Pillai
    Hans Raj Bhat
    Amita Verma
    Udaya Pratap Singh
    Scientific Reports, 7
  • [32] Discovery of novel naphthalene-based diarylamides as pan-Raf kinase inhibitors with promising anti-melanoma activity: rational design, synthesis, in vitro and in silico screening
    Elkamhawy, Ahmed
    Ammar, Usama M.
    Kim, Minkyoung
    Gul, Anam Rana
    Park, Tae Jung
    Lee, Kyeong
    ARCHIVES OF PHARMACAL RESEARCH, 2025, 48 (02) : 150 - 165
  • [33] Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors
    Hopkins, Brian T.
    Bame, Eris
    Bell, Noah
    Bohnert, Tonika
    Bowden-Verhoek, Jon K.
    Bui, Minna
    Cancilla, Mark T.
    Conlon, Patrick
    Cullen, Patrick
    Erlanson, Daniel A.
    Fan, Junfa
    Fuchs-Knotts, Tarra
    Hansen, Stig
    Heumann, Stacey
    Jenkins, Tracy J.
    Gua, Chuck
    Liu, Ying
    Liu, YuTing
    Lulla, Mukush
    Marcotte, Douglas
    Marx, Isaac
    McDowell, Bob
    Mertsching, Elisabeth
    Negrou, Ella
    Romanowski, Michael J.
    Scott, Daniel
    Silvian, Laura
    Yang, Wenjin
    Zhong, Min
    BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 44
  • [34] Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer and anti-inflammatory activities
    Fadaly, Wael A. A.
    Nemr, Mohamed T. M.
    Kahk, Nesma M.
    BIOORGANIC CHEMISTRY, 2024, 147
  • [35] Discovery of a novel class anti-proliferative agents and potential inhibitors of EGFR tyrosine kinases based on 4-anilinotetrahydropyrido[4,3-d]pyrimidine scaffold: Design, synthesis and biological evaluations
    Zhang, Yong
    Zhang, Kai
    Zhao, Meng
    Zhang, Lixia
    Qin, Mingze
    Guo, Shuchun
    Zhao, Yanfang
    Gong, Ping
    BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (15) : 4591 - 4607
  • [36] Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide]
    Mahajan, S
    Ghosh, S
    Sudbeck, EA
    Zheng, YG
    Downs, S
    Hupke, M
    Uckun, FM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (14) : 9587 - 9599
  • [37] Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK):: LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,3-dibromophenyl) propenamide].
    Uckun, FM
    Sudbeck, EA
    Zheng, YG
    Mahajan, S
    Ghosh, S
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 217 : U1199 - U1199
  • [38] Discovery of novel naphthalene-based diarylamides as pan-Raf kinase inhibitors with promising anti-melanoma activity: rational design, synthesis, in vitro and in silico screeningDiscovery of novel naphthalene-based diarylamides as pan-Raf kinase inhibitorsA. Elkamhawy et al.
    Ahmed Elkamhawy
    Usama M. Ammar
    Minkyoung Kim
    Anam Rana Gul
    Tae Jung Park
    Kyeong Lee
    Archives of Pharmacal Research, 2025, 48 (2) : 150 - 165
  • [39] Type IIA - Type IIB protein tyrosine kinase inhibitors hybridization as an efficient approach for potent multikinase inhibitor development: Design, synthesis, anti-proliferative activity, multikinase inhibitory activity and molecular modeling of novel indolinone-based ureides and amides
    Eldehna, Wagdy M.
    El Kerdawy, Ahmed M.
    Al-Ansary, Ghada H.
    Al-Rashood, Sara T.
    Ali, Mamdouh M.
    Mahmoud, Abeer E.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 163 : 37 - 53