Biomimetic total synthesis of litseaverticillols A, C, D, F, and G: Singlet-oxygen-initiated cascades

被引：64

作者：

Vassilikogiannakis, G ^{[1
]}

Stratakis, M ^{[1
]}

机构：

[1] Univ Crete, Dept Chem, Iraklion 71409, Crete, Greece

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 44期

关键词：

biomimetic synthesis; ene reaction; natural products; singlet oxygen; total synthesis;

D O I：

10.1002/anie.200352180

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Natural weapons against HIV, litseaverticillols A (2) and C, have been synthesized from sesquirosefuran (1) by a rapid and efficient biomimetic total synthesis involving a chemo- and stereoselective singlet-oxygen-initiated tandem sequence (see scheme). Litseaverticillols D, F, and G were readily synthesized from litseaverticillol A through a regioselective 1O 2 ene reaction.

引用

页码：5465 / 5468

页数：4

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