Molecular classification of hepatocellular adenoma in clinical practice

被引：106
作者：
Nault, Jean-Charles [1 ,2 ,3 ]
Paradis, Valerie [4 ,5 ,6 ]
Cherqui, Daniel [7 ]
Vilgrain, Valerie [5 ,8 ,9 ]
Zucman-Rossi, Jessica [1 ,10 ,11 ]
机构：
[1] INSERM, Unite Mixte Rech 1162, Genom Fonct Tumeurs Solides, Paris, France
[2] Hop Univ Paris Seine St Denis, Hop Jean Verdier, AP HP, Liver Unit, Bondy, France
[3] Communaute Univ & Etab, Univ Paris 13, Sorbonne Paris Cite, Unite Format & Rech Sante Med & Biol Humaine, Paris, France
[4] Beaujon Hosp, AP HP, Pathol Dept, F-92110 Clichy, France
[5] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France
[6] Paris Diderot Univ, Inflammat Res Ctr, INSERM, UMR 1149, Paris, France
[7] Univ Paris Sud, Paul Brousse Hosp, Hepatobiliary Ctr, INSERM,U1193, 14 Ave Paul Vaillant Couturier, F-94800 Villejuif, France
[8] Univ Hosp Paris Nord Val Seine, Dept Radiol, Clichy, Hauts De Seine, France
[9] CRB3 Paris, Ctr Rech Biomed Bichat Beaujon, INSERM, U1149, Paris, France
[10] Univ Paris 05, Sorbonne Paris Cite, Labex Immunooncol, Fac Med, Paris, France
[11] Hop Europeen Georges Pompidou, AP HP, F-75015 Paris, France
来源：
JOURNAL OF HEPATOLOGY | 2017年 / 67卷 / 05期
关键词：
Hepatocellular adenoma; Molecular classification; HNF1A; beta-Catenin; Sonic hedgehog; FOCAL NODULAR HYPERPLASIA; LIVER ADENOMATOSIS; ACTIVATING MUTATIONS; RISK-FACTORS; MANAGEMENT; INACTIVATION; DIAGNOSIS; FEATURES; MARKERS; PHENOTYPE;
D O I：
10.1016/j.jhep.2017.07.009
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatocellular adenomas (HCA) are rare benign liver tumors occurring in young women taking contraception. They are associated with rare complications such as bleeding or malignant transformation into hepatocellular carcinoma. A molecular classification has divided HCA in several subgroups linked with risk factors, clinical behaviour, histological features and imaging: HNF1A inactivated HCA, Inflammatory HCA, CTNNB1 mutated HCA in exon 3, CTNNB1 mutated in exon 7 and 8 HCA, sonic hedgehog HCA and unclassified HCA. CTNNB1 mutated HCA in exon 3 and sonic hedgehog HCA have been linked with a high risk of malignant transformation and bleeding respectively. Herein, we review how molecular classification has modified our understanding of the pathophysiology and risk factors of HCA development, analysing its impact on clinical care in the field of diagnosis and therapeutic stratification. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1074 / 1083
页数：10
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