Synthesis of C5-tetrazole derivatives of 2-amino-adipic acid displaying NMDA glutamate receptor antagonism

被引：10

作者：

Lenda, Fatimazohra ^{[1
,2
]}

Crouzin, Nadine ^{[1
]}

Cavalier, Melanie ^{[1
]}

Guiramand, Janique ^{[1
]}

Lante, Fabien ^{[1
]}

Barbanel, Gerard ^{[1
]}

Cohen-Solal, Catherine ^{[1
]}

Martinez, Jean ^{[1
]}

Guenoun, Farhate ^{[2
]}

Lamaty, Frederic ^{[1
]}

Vignes, Michel ^{[1
]}

机构：

[1] Univ Montpellier I, Inst Biomol Max Mousseron, CNRS, UMR 5247, F-34095 Montpellier 5, France

[2] Univ Moulay Ismail, Fac Sci, Zitoune, Meknes, Morocco

来源：

AMINO ACIDS | 2011年 / 40卷 / 03期

关键词：

Glutamate; N-Methyl-D-Aspartate (NMDA); Synaptic transmission; Extrasynaptic receptors; EXCITATORY AMINO-ACID; HIPPOCAMPAL CULTURES; ALZHEIMERS-DISEASE; LOW-AFFINITY; CELL-DEATH; NEURONS; MEMANTINE; AGONIST; PHARMACOLOGY; MECHANISM;

D O I：

10.1007/s00726-010-0713-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five derivatives of 2-amino-adipic acid bearing a tetrazole-substituted in C5 position were synthesized. These compounds displayed selective antagonism towards N-methyl-d-aspartate (NMDA) receptors compared with AMPA receptors, and they were devoid of any neurotoxicity. Among these five analogues, one exhibited a higher affinity for synaptic NMDA responses than the other four. Therefore, C5 tetrazole-substituted of 2-amino-adipic acid represent an interesting series of new NMDA receptor antagonists. This approach may be considered as a new strategy to develop ligands specifically targeted to synaptic or extra-synaptic NMDA receptors.

引用

页码：913 / 922

页数：10

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