Localization of mouse mitochondrial SIRT proteins: Shift of SIRT3 to nucleus by co-expression with SIRT5

被引：104

作者：

Nakamura, Yasuhiko ^{[1
]}

Ogura, Masahito ^{[1
]}

Tanaka, Daisuke ^{[1
]}

Inagaki, Nobuya ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Diabet & Clin Nutr, Kyoto 6068507, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 366卷 / 01期

关键词：

SIRT3; SIRT4; SIRT5 intramitochondrial localization; localization shift;

D O I：

10.1016/j.bbrc.2007.11.122

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Yeast silent information regulator 2 (SIR2) is involved in extension of yeast longevity by calorie restriction, and SIRT3, SIRT4, and SIRT5 are mammalian homologs of SIR2 localized in mitochondria. We have investigated the localization of these three SIRT proteins of mouse. SIRT3, SIRT4, and SIRT5 proteins were localized in different compartments of the mitochondria. When SIRT3 and SIRT5 were co-expressed in the cell, localization of SIRT3 protein changed from mitochondria to nucleus. These results suggest that the SIRT3, SIRT4, and SIRT5 proteins exert distinct functions in mitochondria. In addition, the SIRT3 protein might function in nucleus. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：174 / 179

页数：6

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