Peroxisome Metabolism and Cellular Aging

被引：124
作者：
Titorenko, Vladimir I. [1 ]
Terlecky, Stanley R. [2 ]
机构：
[1] Concordia Univ, Dept Biol, Montreal, PQ H4B 1R6, Canada
[2] Wayne State Univ, Dept Pharmacol, Sch Med, Detroit, MI 48201 USA
来源：
TRAFFIC | 2011年 / 12卷 / 03期
基金：
美国国家卫生研究院; 加拿大创新基金会; 加拿大自然科学与工程研究理事会;
关键词：
anaplerotic metabolism; cell death; cellular aging; fatty acid oxidation; hormesis; longevity; mitochondrial retrograde signaling; organelle biogenesis and function; peroxisome; protein degradation; reactive oxygen species; signal transduction; CHRONOLOGICAL LIFE-SPAN; NUCLEAR GENE-EXPRESSION; CATALASE INACTIVATION; HYDROGEN-PEROXIDE; LINKS METABOLISM; STRESS RESPONSES; GENOME STABILITY; BETA-OXIDATION; RTG2; PROTEIN; LON PROTEASE;
D O I：
10.1111/j.1600-0854.2010.01144.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The essential role of peroxisomes in fatty acid oxidation, anaplerotic metabolism, and hydrogen peroxide turnover is well established. Recent findings suggest that these and other related biochemical processes governed by the organelle may also play a critical role in regulating cellular aging. The goal of this review is to summarize and integrate into a model the evidence that peroxisome metabolism actually helps define the replicative and chronological age of a eukaryotic cell. In this model, peroxisomal reactive oxygen species (ROS) are seen as altering organelle biogenesis and function, and eliciting changes in the dynamic communication networks that exist between peroxisomes and other cellular compartments. At low levels, peroxisomal ROS activate an anti-aging program in the cell; at concentrations beyond a specific threshold, a pro-aging course is triggered.
引用
收藏
页码：252 / 259
页数：8
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