Vital involvement of a natural killer cell activation receptor in resistance to viral infection

被引：490

作者：

Brown, MG

Dokun, AO

Heusel, JW

Smith, HRC

Beckman, DL

Blattenberger, EA

Dubbelde, CE

Stone, LR

Scalzo, AA

Yokoyama, WM ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Howard Hughes Med Inst, Div Rheumatol, St Louis, MO 63110 USA

[2] Mt Sinai Sch Med, Immunobiol Grad Program, New York, NY 10029 USA

[3] Univ Western Australia, Dept Microbiol, Nedlands, WA 6907, Australia

来源：

SCIENCE | 2001年 / 292卷 / 5518期

关键词：

D O I：

10.1126/science.1060042

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)-containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.

引用

页码：934 / 937

页数：4

共 25 条

[1] Toll-like receptors in the induction of the innate immune response [J].