Humoral and cellular immunity and the safety of COVID-19 vaccines: a summary of data published by 21 May 2021

被引：41

作者：

Xu, Kun ^{[1
]}

Dai, Lianpan ^{[1
,2
]}

Gao, George F. ^{[2
]}

机构：

[1] Hainan Med Univ, Affiliated Hosp 1, Sch Trop Med & Lab Med, Key Lab Trop Translat Med,Minist Educ, Haikou 571199, Hainan, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

来源：

INTERNATIONAL IMMUNOLOGY | 2021年 / 33卷 / 10期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

antibody; SARS-CoV-2; T cell; variant; CONTROLLED PHASE-2 TRIAL; HEALTHY-ADULTS; DOUBLE-BLIND; RNA VACCINE; SARS-COV; IMMUNOGENICITY; ANTIBODY; MICE; IMMUNIZATION; CHALLENGE;

D O I：

10.1093/intimm/dxab061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coronavirus disease 2019 (COVID-19) has caused millions of deaths, and serious consequences to public health, economies and societies. Rapid responses in vaccine development have taken place since the isolation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the release of the viral genome sequence. By 21 May 2021, 101 vaccines were under clinical trials, and published data were available for 18 of them. Clinical study results from some vaccines indicated good immunogenicity and acceptable reactogenicity. Here, we focus on these 18 vaccines that had published clinical data to dissect the induced humoral and cellular immune responses as well as their safety profiles and protection efficacy.

引用

页码：529 / 540

页数：12

共 130 条

[81] BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans [J].

Sahin, Ugur ;

Muik, Alexander ;

Vogler, Isabel ;

Derhovanessian, Evelyna ;

Kranz, Lena M. ;

Vormehr, Mathias ;

Quandt, Jasmin ;

Bidmon, Nicole ;

Ulges, Alexander ;

Baum, Alina ;

Pascal, Kristen E. ;

Maurus, Daniel ;

Brachtendorf, Sebastian ;

Loerks, Verena ;

Sikorski, Julian ;

Koch, Peter ;

Hilker, Rolf ;

Becker, Dirk ;

Eller, Ann-Kathrin ;

Gruetzner, Jan ;

Tonigold, Manuel ;

Boesler, Carsten ;

Rosenbaum, Corinna ;

Heesen, Ludwig ;

Kuhnle, Marie-Cristine ;

Poran, Asaf ;

Dong, Jesse Z. ;

Luxemburger, Ulrich ;

Kemmer-Brueck, Alexandra ;

Langer, David ;

Bexon, Martin ;

Bolte, Stefanie ;

Palanche, Tania ;

Schultz, Armin ;

Baumann, Sybille ;

Mahiny, Azita J. ;

Boros, Gabor ;

Reinholz, Jonas ;

Szabo, Gabor T. ;

Kariko, Katalin ;

Shi, Pei-Yong ;

Fontes-Garfias, Camila ;

Perez, John L. ;

Cutler, Mark ;

Cooper, David ;

Kyratsous, Christos A. ;

Dormitzer, Philip R. ;

Jansen, Kathrin U. ;

Tuereci, Oezlem .

NATURE, 2021, 595 (7868) :572-+

[82] COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses [J].

Sahin, Ugur ;

Muik, Alexander ;

Derhovanessian, Evelyna ;

Vogler, Isabel ;

Kranz, Lena M. ;

Vormehr, Mathias ;

Baum, Alina ;

Pascal, Kristen ;

Quandt, Jasmin ;

Maurus, Daniel ;

Brachtendorf, Sebastian ;

Loerks, Verena ;

Sikorski, Julian ;

Hilker, Rolf ;

Becker, Dirk ;

Eller, Ann-Kathrin ;

Gruetzner, Jan ;

Boesler, Carsten ;

Rosenbaum, Corinna ;

Kuehnle, Marie-Cristine ;

Luxemburger, Ulrich ;

Kemmer-Brueck, Alexandra ;

Langer, David ;

Bexon, Martin ;

Bolte, Stefanie ;

Kariko, Katalin ;

Palanche, Tania ;

Fischer, Boris ;

Schultz, Armin ;

Shi, Pei-Yong ;

Fontes-Garfias, Camila ;

Perez, John L. ;

Swanson, Kena A. ;

Loschko, Jakob ;

Scully, Ingrid L. ;

Cutler, Mark ;

Kalina, Warren ;

Kyratsous, Christos A. ;

Cooper, David ;

Dormitzer, Philip R. ;

Jansen, Kathrin U. ;

Tuereci, Oezlem .

NATURE, 2020, 586 (7830) :594-+

[83] Inactivated COVID-19 vaccine BBV152/COVAXIN effectively neutralizes recently emerged B.1.1.7 variant of SARS-CoV-2 [J].

Sapkal, Gajanan N. ;

Yadav, Pragya D. ;

Ella, Raches ;

Deshpande, Gururaj R. ;

Sahay, Rima R. ;

Gupta, Nivedita ;

Vadrevu, Krishna Mohan ;

Abraham, Priya ;

Panda, Samiran ;

Bhargava, Balram .

JOURNAL OF TRAVEL MEDICINE, 2021, 28 (04)

[84] Toll-like receptors control activation of adaptive immune responses [J].

Schnare, M ;

Barton, GM ;

Holt, AC ;

Takeda, K ;

Akira, S ;

Medzhitov, R .

NATURE IMMUNOLOGY, 2001, 2 (10) :947-950

[85] Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 [J].

Sekine, Takuya ;

Perez-Potti, Andre ;

Rivera-Ballesteros, Olga ;

Stralin, Kristoffer ;

Gorin, Jean-Baptiste ;

Olsson, Annika ;

Llewellyn-Lacey, Sian ;

Kamal, Habiba ;

Bogdanovic, Gordana ;

Muschiol, Sandra ;

Wullimann, David J. ;

Kammann, Tobias ;

Emgard, Johanna ;

Parrot, Tiphaine ;

Folkesson, Elin ;

Rooyackers, Olav ;

Eriksson, Lars, I ;

Henter, Jan-Inge ;

Sonnerborg, Anders ;

Allander, Tobias ;

Albert, Jan ;

Nielsen, Morten ;

Klingstrom, Jonas ;

Gredmark-Russ, Sara ;

Bjorkstrom, Niklas K. ;

Sandberg, Johan K. ;

Price, David A. ;

Ljunggren, Hans-Gustaf ;

Aleman, Soo ;

Buggert, Marcus .

CELL, 2020, 183 (01) :158-+

[86] Cold-Adapted Live Attenuated SARS-Cov-2 Vaccine Completely Protects Human ACE2 Transgenic Mice from SARS-Cov-2 Infection [J].

Seo, Sang Heui ;

Jang, Yunyueng .

VACCINES, 2020, 8 (04) :1-17

[87] SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines [J].

Shen, Xiaoying ;

Tang, Haili ;

McDanal, Charlene ;

Wagh, Kshitij ;

Fischer, William ;

Theiler, James ;

Yoon, Hyejin ;

Li, Dapeng ;

Haynes, Barton F. ;

Sanders, Kevin O. ;

Gnanakaran, Sandrasegaram ;

Hengartner, Nick ;

Pajon, Rolando ;

Smith, Gale ;

Glenn, Gregory M. ;

Korber, Bette ;

Montefiori, David C. .

CELL HOST & MICROBE, 2021, 29 (04) :529-+

[88] Neutralization of SARS-CoV-2 Variants B.1.429 and B.1.351 [J].

Shen, Xiaoying ;

Tang, Haili ;

Pajon, Rolando ;

Smith, Gale ;

Glenn, Gregory M. ;

Shi, Wei ;

Korber, Bette ;

Montefiori, David C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (24) :2352-2354

[89] A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2 [J].

Shi, Rui ;

Shan, Chao ;

Duan, Xiaomin ;

Chen, Zhihai ;

Liu, Peipei ;

Song, Jinwen ;

Song, Tao ;

Bi, Xiaoshan ;

Han, Chao ;

Wu, Lianao ;

Gao, Ge ;

Hu, Xue ;

Zhang, Yanan ;

Tong, Zhou ;

Huang, Weijin ;

Liu, William Jun ;

Wu, Guizhen ;

Zhang, Bo ;

Wang, Lan ;

Qi, Jianxun ;

Feng, Hui ;

Wang, Fu-Sheng ;

Wang, Qihui ;

Gao, George Fu ;

Yuan, Zhiming ;

Yan, Jinghua .

NATURE, 2020, 584 (7819) :120-+

[90]

Shimabukuro T, 2021, MMWR-MORBID MORTAL W, V70, P125, DOI [10.1111/ajt.16517, 10.15585/mmwr.mm7004e1]

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