Humoral and cellular immunity and the safety of COVID-19 vaccines: a summary of data published by 21 May 2021

被引:35
作者
Xu, Kun [1 ]
Dai, Lianpan [1 ,2 ]
Gao, George F. [2 ]
机构
[1] Hainan Med Univ, Affiliated Hosp 1, Sch Trop Med & Lab Med, Key Lab Trop Translat Med,Minist Educ, Haikou 571199, Hainan, Peoples R China
[2] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
antibody; SARS-CoV-2; T cell; variant; CONTROLLED PHASE-2 TRIAL; HEALTHY-ADULTS; DOUBLE-BLIND; RNA VACCINE; SARS-COV; IMMUNOGENICITY; ANTIBODY; MICE; IMMUNIZATION; CHALLENGE;
D O I
10.1093/intimm/dxab061
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Coronavirus disease 2019 (COVID-19) has caused millions of deaths, and serious consequences to public health, economies and societies. Rapid responses in vaccine development have taken place since the isolation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the release of the viral genome sequence. By 21 May 2021, 101 vaccines were under clinical trials, and published data were available for 18 of them. Clinical study results from some vaccines indicated good immunogenicity and acceptable reactogenicity. Here, we focus on these 18 vaccines that had published clinical data to dissect the induced humoral and cellular immune responses as well as their safety profiles and protection efficacy.
引用
收藏
页码:529 / 540
页数:12
相关论文
共 130 条
[1]   Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants [J].
Abu-Raddad, Laith J. ;
Chemaitelly, Hiam ;
Butt, Adeel A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (02) :187-189
[2]   Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus [J].
Agrawal, Anurodh Shankar ;
Tao, Xinrong ;
Algaissi, Abdullah ;
Garron, Tania ;
Narayanan, Krishna ;
Peng, Bi-Hung ;
Couch, Robert B. ;
Tseng, Chien-Te K. .
HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2016, 12 (09) :2351-2356
[3]   Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults A Randomized Clinical Trial [J].
Al Kaabi, Nawal ;
Zhang, Yuntao ;
Xia, Shengli ;
Yang, Yunkai ;
Al Qahtani, Manaf M. ;
Abdulrazzaq, Najiba ;
Al Nusair, Majed ;
Hassany, Mohamed ;
Jawad, Jaleela S. ;
Abdalla, Jehad ;
Hussein, Salah Eldin ;
Al Mazrouei, Shamma K. ;
Al Karam, Maysoon ;
Li, Xinguo ;
Yang, Xuqin ;
Wang, Wei ;
Lai, Bonan ;
Chen, Wei ;
Huang, Shihe ;
Wang, Qian ;
Yang, Tian ;
Liu, Yang ;
Ma, Rui ;
Hussain, Zaidoon M. ;
Khan, Tehmina ;
Saifuddin Fasihuddin, Mohammed ;
You, Wangyang ;
Xie, Zhiqiang ;
Zhao, Yuxiu ;
Jiang, Zhiwei ;
Zhao, Guoqing ;
Zhang, Yanbo ;
Mahmoud, Sally ;
ElTantawy, Islam ;
Xiao, Peng ;
Koshy, Ashish ;
Zaher, Walid Abbas ;
Wang, Hui ;
Duan, Kai ;
Pan, An ;
Yang, Xiaoming .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 326 (01) :35-45
[4]   Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults [J].
Anderson, E. J. ;
Rouphael, N. G. ;
Widge, A. T. ;
Jackson, L. A. ;
Roberts, P. C. ;
Makhene, M. ;
Chappell, J. D. ;
Denison, M. R. ;
Stevens, L. J. ;
Pruijssers, A. J. ;
McDermott, A. B. ;
Flach, B. ;
Lin, B. C. ;
Doria-Rose, N. A. ;
O'Dell, S. ;
Schmidt, S. D. ;
Corbett, K. S. ;
Swanson, P. A., II ;
Padilla, M. ;
Neuzil, K. M. ;
Bennett, H. ;
Leav, B. ;
Makowski, M. ;
Albert, J. ;
Cross, K. ;
Edara, V. V. ;
Floyd, K. ;
Suthar, M. S. ;
Martinez, D. R. ;
Baric, R. ;
Buchanan, W. ;
Luke, C. J. ;
Phadke, V. K. ;
Rostad, C. A. ;
Ledgerwood, J. E. ;
Graham, B. S. ;
Beigel, J. H. .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (25) :2427-2438
[5]   SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma [J].
Andreano, Emanuele ;
Piccini, Giulia ;
Licastro, Danilo ;
Casalino, Lorenzo ;
Johnson, Nicole, V ;
Paciello, Ida ;
Dal Monego, Simeone ;
Pantano, Elisa ;
Manganaro, Noemi ;
Manenti, Alessandro ;
Manna, Rachele ;
Casa, Elisa ;
Hyseni, Inesa ;
Benincasa, Linda ;
Montomoli, Emanuele ;
Amaro, Rommie E. ;
McLellan, Jason S. ;
Rappuoli, Rino .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (36)
[6]   A perspective on potential antibody-dependent enhancement of SARS-CoV-2 [J].
Arvin, Ann M. ;
Fink, Katja ;
Schmid, Michael A. ;
Cathcart, Andrea ;
Spreafico, Roberto ;
Havenar-Daughton, Colin ;
Lanzavecchia, Antonio ;
Corti, Davide ;
Virgin, Herbert W. .
NATURE, 2020, 584 (7821) :353-363
[7]   Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].
Baden, Lindsey R. ;
El Sahly, Hana M. ;
Essink, Brandon ;
Kotloff, Karen ;
Frey, Sharon ;
Novak, Rick ;
Diemert, David ;
Spector, Stephen A. ;
Rouphael, Nadine ;
Creech, C. Buddy ;
McGettigan, John ;
Khetan, Shishir ;
Segall, Nathan ;
Solis, Joel ;
Brosz, Adam ;
Fierro, Carlos ;
Schwartz, Howard ;
Neuzil, Kathleen ;
Corey, Larry ;
Gilbert, Peter ;
Janes, Holly ;
Follmann, Dean ;
Marovich, Mary ;
Mascola, John ;
Polakowski, Laura ;
Ledgerwood, Julie ;
Graham, Barney S. ;
Bennett, Hamilton ;
Pajon, Rolando ;
Knightly, Conor ;
Leav, Brett ;
Deng, Weiping ;
Zhou, Honghong ;
Han, Shu ;
Ivarsson, Melanie ;
Miller, Jacqueline ;
Zaks, Tal .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416
[8]   Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses [J].
Barrett, Jordan R. ;
Belij-Rammerstorfer, Sandra ;
Dold, Christina ;
Ewer, Katie J. ;
Folegatti, Pedro M. ;
Gilbride, Ciaran ;
Halkerston, Rachel ;
Hill, Jennifer ;
Jenkin, Daniel ;
Stockdale, Lisa ;
Verheul, Marije K. ;
Aley, Parvinder K. ;
Angus, Brian ;
Bellamy, Duncan ;
Berrie, Eleanor ;
Bibi, Sagida ;
Bittaye, Mustapha ;
Carroll, Miles W. ;
Cavell, Breeze ;
Clutterbuck, Elizabeth A. ;
Edwards, Nick ;
Flaxman, Amy ;
Fuskova, Michelle ;
Gorringe, Andrew ;
Hallis, Bassam ;
Kerridge, Simon ;
Lawrie, Alison M. ;
Linder, Aline ;
Liu, Xinxue ;
Madhavan, Meera ;
Makinson, Rebecca ;
Mellors, Jack ;
Minassian, Angela ;
Moore, Maria ;
Mujadidi, Yama ;
Plested, Emma ;
Poulton, Ian ;
Ramasamy, Maheshi N. ;
Robinson, Hannah ;
Rollier, Christine S. ;
Song, Rinn ;
Snape, Matthew D. ;
Tarrant, Richard ;
Taylor, Stephen ;
Thomas, Kelly M. ;
Voysey, Merryn ;
Watson, Marion E. E. ;
Wright, Daniel ;
Douglas, Alexander D. ;
Green, Catherine M. .
NATURE MEDICINE, 2021, 27 (02) :279-+
[9]   The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection [J].
Beddingfield, Brandon J. ;
Iwanaga, Naoki ;
Chapagain, Prem P. ;
Zheng, Wenshu ;
Roy, Chad J. ;
Hu, Tony Y. ;
Kolls, Jay K. ;
Bix, Gregory J. .
JACC-BASIC TO TRANSLATIONAL SCIENCE, 2021, 6 (01) :1-8
[10]   A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response [J].
Bolles, Meagan ;
Deming, Damon ;
Long, Kristin ;
Agnihothram, Sudhakar ;
Whitmore, Alan ;
Ferris, Martin ;
Funkhouser, William ;
Gralinski, Lisa ;
Totura, Allison ;
Heise, Mark ;
Baric, Ralph S. .
JOURNAL OF VIROLOGY, 2011, 85 (23) :12201-12215