Humoral and cellular immunity and the safety of COVID-19 vaccines: a summary of data published by 21 May 2021

被引：35

作者：

Xu, Kun ^{[1
]}

Dai, Lianpan ^{[1
,2
]}

Gao, George F. ^{[2
]}

机构：

[1] Hainan Med Univ, Affiliated Hosp 1, Sch Trop Med & Lab Med, Key Lab Trop Translat Med,Minist Educ, Haikou 571199, Hainan, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

来源：

INTERNATIONAL IMMUNOLOGY | 2021年 / 33卷 / 10期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

antibody; SARS-CoV-2; T cell; variant; CONTROLLED PHASE-2 TRIAL; HEALTHY-ADULTS; DOUBLE-BLIND; RNA VACCINE; SARS-COV; IMMUNOGENICITY; ANTIBODY; MICE; IMMUNIZATION; CHALLENGE;

D O I：

10.1093/intimm/dxab061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coronavirus disease 2019 (COVID-19) has caused millions of deaths, and serious consequences to public health, economies and societies. Rapid responses in vaccine development have taken place since the isolation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the release of the viral genome sequence. By 21 May 2021, 101 vaccines were under clinical trials, and published data were available for 18 of them. Clinical study results from some vaccines indicated good immunogenicity and acceptable reactogenicity. Here, we focus on these 18 vaccines that had published clinical data to dissect the induced humoral and cellular immune responses as well as their safety profiles and protection efficacy.

引用

页码：529 / 540

页数：12

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