Effects of resveratrol on cariogenic virulence properties of Streptococcus mutans

被引：7
|
作者：
Li, Jinheng [1 ,2 ]
Wu, Tiantian [1 ,2 ]
Peng, Weiwei [1 ,2 ]
Zhu, Yaqin [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Stomatol,Shanghai Key Lab Stomatol, Dept Gen Dent,Sch Med,Natl Clin Res Ctr Oral Dis, 639 Zhi Zao Ju Rd, Shanghai 200011, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Stomatol,Shanghai Res Inst Stomatol, Dept Gen Dent,Sch Med,Natl Clin Res Ctr Oral Dis, 639 Zhi Zao Ju Rd, Shanghai 200011, Peoples R China
来源：
BMC MICROBIOLOGY | 2020年 / 20卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Resveratrol; Streptococcus mutans; Acidogenicity; Aciduricity; Extracellular polysaccharide; Biofilm; ACID PRODUCTION; FLUORIDE; BIOFILM; INHIBITION; SEPARATION; BACTERIA;
D O I：
10.1186/s12866-020-01761-3
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Background Streptococcus mutans is the principal etiological agent of human dental caries. The major virulence factors of S. mutans are acid production, acid tolerance, extracellular polysaccharide (EPS) synthesis and biofilm formation. The aim of this study is to evaluate the effect of resveratrol, a natural compound, on virulence properties of S. mutans. Results Resveratrol at sub-MIC levels significantly decreased acid production and acid tolerance, inhibited synthesis of water-soluble polysaccharide and water-insoluble polysaccharide, compromised biofilm formation. Related virulence gene expression (ldh, relA, gtfC, comDE) was down-regulated with increasing concentrations of resveratrol. Conclusions Resveratrol has an inhibitory effect on S. mutans cariogenic virulence properties and it represents a promising anticariogenic agent.
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页数：11
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