Electrochemistry and voltammetric determination of furazolidone with a multi-walled nanotube composite film-glassy carbon electrode

This study describes the electrochemical properties of furazolidone (Fu) at a glassy carbon electrode (GCE) modified with a multi-walled carbon nanotube (MWCNT) composite film. Cyclic voltammetry and chronoamperometry techniques were used for diagnostic purposes. The electrode (MWCNT-film-modified GCE) exhibited excellent electrocatalytic behavior for the reduction of Fu as evidenced by the enhancement of the 4e-reduction peak current and the shift in the reduction potential to more positive potential (by 50 mV) in comparison with a bare GCE. The formal potential, E (0'), of Fu is pH dependent with a slope of 54.4 mV per unit of pH, close to the anticipated Nernestian value of -59 mV for a four-electron and four-proton processes. The transfer coefficient (alpha), standard rate constant of the surface reaction (k (s)), diffusion coefficient (D), and surface concentration (I") for the MWCNT-film-modified GCE were calculated. On the other hand, Fu can be accumulated effectively on the MWCNT-film-modified GCE. Under the selected experimental conditions, i.e., solution pH 6, accumulation time 10 min, and accumulation potential -0.30 V, the peak current shows a dynamic linear range 3-800 mu M with detection limit 2.30 mu M. The method was successfully applied to analyze pharmaceutical formulations. The method used in this study was further applied for the determination of Fu.