Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway

被引:22
|
作者
Zhu, Xinbing [1 ]
Li, Rongnian [2 ]
Wang, Chen [1 ]
Zhou, Shuo [1 ]
Fan, Yujia [1 ]
Ma, Shuang [1 ]
Gao, Didi [1 ]
Gai, Nian [1 ]
Yang, Jing [3 ]
机构
[1] Jinzhou Med Univ, Affiliated Hosp 1, Dept Breast Surg, Jinzhou, Peoples R China
[2] Panjin Liaohe Oilfield Gem Flower Hosp, Dept Gen Surg, Panjin, Peoples R China
[3] China Med Univ, Shengjing Hosp, Dept Otolaryngol Head & Neck Surg, Shenyang, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
关键词
pinocembrin; breast cancer; cell cycle; apoptosis; PI3K/AKT signaling pathway; CELL-CYCLE ARREST; IN-VITRO; APOPTOSIS; EXTRACT; EXPRESSION; SURVIVIN; PTEN;
D O I
10.3389/fonc.2021.661184
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The survival rate of breast cancer (BC) patients remains poor, thus the identification of safe and effective new drugs is crucial to improve therapeutic outcomes and overall survival. Pinocembrin (PCB), a pharmacologically active ingredient of Pinus heartwood, Eucalyptus, Euphorbia, Populus, and Sparattosperma leucanthum, has been widely applied for the treatment of various diseases and possesses anticancer activities. In vitro assays were performed to investigate the antiproliferation and antimetastasis activities of PCB in BC cells. A tumorigenesis assay with the use of murine BC models was performed to assess the antiproliferation activities of PCB in vivo. Moreover, the molecular mechanisms underlying the anticancer activities of PCB in BC cells were explored. The results showed that the anti-inhibitory and antiproliferation activities of PCB in BC might involve cell cycle (G2/M phase) arrest and apoptosis. PCB downregulated the expression levels of proteins involved in cell cycle progression and apoptosis, including cyclinB1, Cdc2, PARP1, Bcl-2, and survivin, and upregulated protein levels of cleaved PARP1, cleaved caspase3, cleaved caspase9, and BAX. In a murine subcutaneous tumor model, PCB suppressed the growth of MCF-7 cells in vivo. Low concentrations of PCB also significantly inhibited the migration and invasion abilities of BC cells. Mechanistically, PCB administration was correlated to suppression of the PI3K/AKT signaling pathway. Inhibition of the proliferation of BC cells by PCB involved cell cycle (G2/M phase) arrest and apoptosis in vitro and in vivo. Low concentrations of PCB also significantly inhibited the migration and invasion abilities of BC cells. These findings suggest that PCB might be an effective agent for treatment of BC patients.
引用
收藏
页数:13
相关论文
共 50 条
  • [41] Topiramate inhibits the proliferation of bladder cancer cells via PI3K/AKTR signaling pathway
    Chao, Liu
    Zhang, Shaoqi
    Zhang, Jianjun
    Cai, Longjun
    Wang, Xiangyu
    Meng, Fanlai
    Cai, Weiqi
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2022, 21 (04) : 685 - 691
  • [42] Osthole suppresses the proliferation and induces apoptosis via inhibiting the PI3K/AKT signaling pathway of endometrial cancer JEC cells
    Liang, Lei
    Yang, Bo
    Wu, Yuanyuan
    Sun, Li
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021, 22 (04)
  • [43] Ropivacaine inhibits wound healing by suppressing the proliferation and migration of keratinocytes via the PI3K/AKT/mTOR Pathway
    Wu, Xiaoyang
    Sun, Quanyu
    He, Simeng
    Wu, Ya
    Du, Shihan
    Gong, Lirong
    Yu, Jianbo
    Guo, Haifeng
    BMC ANESTHESIOLOGY, 2022, 22 (01)
  • [44] 3-Epipachysamine B suppresses proliferation and induces apoptosis of breast cancer cell via PI3K/AKT/mTOR signaling pathway
    Zhang, Lei
    Zheng, Yi
    Zeng, Lizhong
    Zhang, Fuxin
    Che, Delu
    Cao, Zhen
    Huang, Chen
    Xian, Liang
    Zhang, Xinxin
    Zhang, Hui
    Guo, Zengjun
    LIFE SCIENCES, 2021, 285
  • [45] KLF2 inhibits colorectal cancer progression and metastasis by inducing ferroptosis via the PI3K/AKT signaling pathway
    Li, Jia
    Jiang, Ji Ling
    Chen, Yi Mei
    Lu, Wei Qi
    JOURNAL OF PATHOLOGY CLINICAL RESEARCH, 2023, 9 (05): : 423 - 435
  • [46] MiR-548k suppresses apoptosis in breast cancer cells by affecting PTEN/PI3K/AKT signaling pathway
    Yadollahi-Farsani, Mahtab
    Amini-Farsani, Zeinab
    Moayedi, Fatemeh
    Khazaei, Niusha
    Yaghoobi, Hajar
    IUBMB LIFE, 2023, 75 (02) : 97 - 116
  • [47] NUCKS1 promotes breast cancer cell proliferation and metastasis via PI3K/AKT pathway
    Li, Song
    Wang, Daoliang
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2022, 21 (10) : 2099 - 2105
  • [48] The Natural Product Fucoidan Inhibits Proliferation and Induces Apoptosis of Human Ovarian Cancer Cells: Focus on the PI3K/Akt Signaling Pathway
    Liu, Shuhan
    Yang, Jing
    Peng, Xudong
    Li, Jingjing
    Zhu, Cunjing
    CANCER MANAGEMENT AND RESEARCH, 2020, 12 : 6195 - 6207
  • [49] The PI3K/AKT/MTOR signaling pathway: The role of PI3K and AKT inhibitors in breast cancer
    Huemer F.
    Bartsch R.
    Gnant M.
    Current Breast Cancer Reports, 2014, 6 (2) : 59 - 70
  • [50] Fentanyl inhibits the progression of gastric cancer through the suppression of MMP-9 via the PI3K/Akt signaling pathway
    Li, Chunlai
    Qin, Yi
    Zhong, Yu
    Qin, Yinying
    Wei, Yi
    Li, Li
    Xie, Yubo
    ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8 (04)