L-Asparaginase-Induced Complete Response in a Relapsed Patient with Epstein-Barr Virus and Cytotoxic Peripheral T-Cell Lymphoma Not Otherwise Specified

被引：5

作者：

Takahashi, Tsutomu ^{[1
]}

Ikejiri, Fumiyoshi ^{[1
]}

Onishi, Chie ^{[1
]}

Kawakami, Koshi ^{[1
]}

Inoue, Masaya ^{[2
]}

Miyake, Takaaki ^{[1
]}

Tanaka, Junko ^{[1
]}

Araki, Asuka ^{[3
]}

Maruyama, Riruke ^{[3
]}

Ohshima, Koichi ^{[4
]}

Suzumiya, Junji ^{[2
]}

机构：

[1] Shimane Univ Hosp, Dept Hematol, Izumo, Shimane, Japan

[2] Shimane Univ Hosp, Ctr Canc, Izumo, Shimane, Japan

[3] Shimane Univ Hosp, Dept Pathol, Izumo, Shimane, Japan

[4] Kurume Univ, Dept Pathol, Kurume, Fukuoka 830, Japan

来源：

INTERNAL MEDICINE | 2010年 / 49卷 / 22期

关键词：

peripheral T-cell lymphoma-NOS; L-asparaginase; Epstein-Barr virus; cytotoxic molecule; hemophagocytic syndrome; PROGNOSTIC-SIGNIFICANCE; LEUKEMIA;

D O I：

10.2169/internalmedicine.49.4083

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We present a patient with Epstein-Barr virus (EBV)-positive cytotoxic peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) who was successfully treated using only L-asparaginase. A 46-year-old Japanese man was diagnosed with EBV-positive cytotoxic PTCL-NOS. Although he underwent chemotherapy using multiple agents, he relapsed with hemophagocytic syndrome. L-asparaginase treatment was initiated at 6,000 U/m(2) on days 1, 3, 5, 10, and 12 together with prednisolone at 1 mg/kg. Although he developed grade 2 liver dysfunction and grade 2 coagulopathy, the patient achieved complete response status. Finally, he underwent allogeneic bone marrow stem cell transplantation, and he is currently still alive without disease at 24 months after the start of L-asparaginase therapy.

引用

页码：2505 / 2508

页数：4

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