Insoluble versus soluble polymer-assisted synthesis.: A first approach for the preparation of a Biginelli compound

被引：5

作者：

Vanden Eynde, JJ ^{[1
]}

Watté, O

机构：

[1] Xavier Univ, Coll Pharm, Div Basic Pharmaceut Sci, 1 Drexel Dr, New Orleans, LA 70125 USA

[2] Univ Mons, Dept Organ Chem, Fac Sci, B-7000 Mons, Belgium

来源：

ARKIVOC | 2003年

关键词：

solid-phase synthesis; liquid-phase synthesis; dendrimer; pyrimidine; Biginelli;

D O I：

10.3998/ark.5550190.0004.408

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A comparison is established between the experimental conditions associated with the multistep synthesis of ethyl 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenylpyrimidine-5-carboxylate from Merrifield's resin and soluble polymers, derived from poly( ethylene glycol), poly( styrene-co-allyl alcohol), or dendritic aliphatic polyols.

引用

页码：93 / 101

页数：9

共 14 条

[1]

Biginelli P., 1893, GAZZ CHIM ITAL, V23, P360

[2]

BONORA GM, 1995, APPL BIOCHEM BIOTECH, V54, P3

[3]

Charlot G., 1966, METHODES CHIMIE ANAL

[4] Organic chemistry on solid supports [J].

Fruchtel, JS ;

Jung, G .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (01) :17-42

[5] Organic synthesis on soluble polymer supports: Liquid-phase methodologies [J].

Gravert, DJ ;

Janda, KD .

CHEMICAL REVIEWS, 1997, 97 (02) :489-509

[6] Solid-phase organic reactions .2. A review of the literature Nov 95 Nov 96. [J].

Hermkens, PHH ;

Ottenheijm, HCJ ;

Rees, DC .

TETRAHEDRON, 1997, 53 (16) :5643-5678

[7] Disaccharide synthesis on a soluble hyperbranched polymer [J].

Kantchev, AB ;

Parquette, JR .

TETRAHEDRON LETTERS, 1999, 40 (46) :8049-8053

[8]

KAPPE CO, 1993, TETRAHEDRON, V49, P6937

[9] Synthesis and reactions of Biginelli compounds, part 17 - Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4-dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage [J].

Kappe, CO .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (01) :49-51

[10] Biologically active dihydropyrimidones of the Biginelli-type - a literature survey [J].

Kappe, CO .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (12) :1043-1052

← 1 2 →